PHARMACOLOGY MCQS-2

1.	Cetrizine is a active metabolite of A.Hydroxyzine       b.promethazine      c.cimetidine      d. Cinnarizine	A
2.	Eicosanoids includes A.Prostaglandins      b. Leukotrienes      c. Thromboxane   d.all	D
3.	In ltb4 the subscript ‘4’ indicates a.No. Of double bonds       b.no. Of conjugated doubles bonds c.C..no. Of  alkyl substitutions      d. No. Of halogens	B
4.	Platelets primarily synthesize a.TXA2          b. PGI2            c. LTB4        d. Histamine	A
5.	Endothelium mainly generates a.PGG2     b..PGI      c. PAF  d. PGF2α	B
6.	All NSAIDS are reversible inhibitors of cyclo oxygenase except a.Aspirin       b.indomethacin      c. Celecoxib      d. Paracetamol	A
7.	N-acetyl-p-benzoquinoneimine is highly reactive heapatotoxic metabolite is of a.Aspirin     b.indomethacin    c. Paracetamol      d.ibuprofen	C
8.	All of the following have arrhythmic potential by prolonging qtc interval except a.Loratadine      b.astemizole       c.terfenadine     d.ebastine	C
9.	Which of the following anti gout drug also inhibits platelet aggregation a.Colchicine     b.sulfinpyrazone     c. Diclofenac    d.allopurinol	B
10.	Which of the following drug have local anesthetic effect also a.Promethazine       b.mepyramine      c.diphenhydramine    d.loratidine	A
11.	Which of the following is not a vasodilator a.PGE2      b. PGI2       c.PGD2         d. PGF2α	D
12.	Serotonin is biosynthesized from a.Tryptophan       b.tyrosine      c. Histidine       d.phenylalanine	A
13.	Histamine is biosynthesized from decarboxylation of a.Tryptophan       b.tyrosine     c. Histidine     d.phenylalanine	C
14.	Nsaids can inhibit the production of all except a.PGI2        b cyclic endoperoxides    c. TXA2      d. Leukotrienes	D
15.	NSAID used for ocular inflammation a.Ibuprofen    b. Piroxicam    c.nimesulide   d.flurbiprofen	D
16.	Which of the following hormone is released from anterior pituitary gland a.Parathormone     b.thyroid stimulating hormone c.vasopressin            d.somatostatin	B
17.	Somatotatin is released from pancreas as well as from a.Hypothalamus       b.anterior pituitary gland   posterior pituitary gland    d. All	A
18.	Which hormone help in adaptation to stress a.Adrenaline     b. Glucocorticoid      c.both     d.parathormone	C
19.	Which of the following help in maintenance of calcium balance a.Vitamin-d      b.parathormone       c.calcitonin      d.all	D
20.	Which of the following hormone is also released from placenta a.estrogen     b.prolactin        c.chorionic gonadotrophin     d.all	D
21.	Match following 1. Dwarfism               a. Growth hormone deficiency in childs 2. Acromegaly b. Growth hormone overproduction in adults 3. Gignatism          c. Growth hormone overproduction in childs 4. Addisons disease  d. Hyposecretion of sex hormone Select a.1-b, 2-a,3-c,4-d        b.1-a,2-b,3-c,4-d c..1-a,2-b,3-d,4-c      d.1-a,2-c,3-b,4-d	B
22.	Match the following 1.        Cushing syndrome a. Hypersecretion of corticosteroid hormone 2.        Cretinism b. Hyposecretion of thyroid hormone in childs 3.        Myxoedema c. Hyposecretion of thyroid hormone in adults 4.        Graves disease d. Autimmune  disease, igg antibodies form against tsh receptor Select a.1-a,2-b,3-c,4-d       b.1-a,2-c,3-b,4-d c.1-d,2-b,3-c,4-a       d.1-d,2-c,3-b,4-d	A
23.	Which preparation is used in growth hormone deficiency (dwarfism) A.somatropin      b.somatrem    c.somatostatin     d.both a and b   e. All	D
24.	Match following 1.octreotide          synthetic and used in acromegaly 2. Cabergoline      d2 agonist 3.nafareline           long acting gnrh agonist Select a.1-a,2-b,3-c      b. 1-b,2-a,3-c c.1-c,2-b,3-a      d.1-a,2-c,3-b	A
25.	Propylthiouracil inhibit peripheral conversion of t4 to t3 by inhibiting a.d1    b.d2    c.both     d.not inhibit peripheral conversion	A
26.	Safe antithyroid therapy in pregnancy a.radioactive iodine    b.propylthiouracil c..carbimazol         d.all	B