CENTRAL NERVOUS SYSTEM MCQS-3

1.Amenorrhoea ,galactorrhoea and gynaecomastia are adverse effect of

a.atypical antipsychotics    b.typical antipsychotics    c.both    d.parkinsonian agents

2. Drug used in mania

a.lithium    b.valproate     c.atypical antipsychoyics       d all

3. Cannabinoids are used as hallucinogens and tetrahydrocannabinol is active constituent of ‘cannabis indica’. now match the source of following

a bhang       1. dried female inflorescence

b.ganja         2 dried leaves

c.charas       3.dried resinous extract from flowering tops and leaves

select correct

A.      a-1,b-2,c-3

B.      a-2,b-1,c-3

C.      a-1,b-3,c-2

D.      a-2,b-3,c-1

 4.Which antiepileptic drug is not  used for absence seizure

A.      phenytoin   b.ethosuximide      c.valproic acid        d.clonazepam

5. spina bifida and neural tube defect caused to foetus by which antiepileptic drug

a phenytoin    b ethosuximide    c valproic acid       d.clonazepam

6 which  antiepileptic drug act by inhibiting ‘t’ type calcium current

a.ethosuximide    b.topiramate      c.phenytoin       d.all of these

7. Which of the following is ultra short acting barbiturate

a.methohexitone     b.thiopentone      c.pentobarbitone        d. a and b

8. Competitive antagonist at bzd site

a.muscimol      b.bicuculline       c.flumazenil      d.beta carboline

9. Comt inhibitor

a.bromocriptine    b.ropinirole       c.entcapone       d.amantadine

10. Carbidopa  inhibit

a.decarboxylase at perpheral site   

b.decarboxylase at cns site

c.both of these      

d. highly lipophilic so inhibit decarboxylase at peripheral site majorly but minorly act at peripheral site also

11. Which is not true about bromocriptine

a.d2 receptor antagonist    b.d1 receptor antagonist  c.d2 receptor agonist   d.d1 receptor partial agonist

12 Which of the following is a ergot derivative

a.ropinirole   b.pramipexole     c carbidopa      d bromocriptine

13. Dopaminergic overactivity in limbic system is related with

a.parkinsonism    b.schozophernia    c.depression      c.all of these

14.Which anti parkinsonian drug is approved for ‘restless leg syndrome’

a.selegeline   b.bromocriptine   c.ropinirole      d.carbidopa

15 Entacapone and tolcapone inhibit the ‘comt’ at

a.both inhibit at peripheral site as well as brain

b.tolcapone inhibit both at peripheral site as well as brain but entacapone inhibit only at brain site only

c. tolcapone inhibit both at peripheral site as well as brain but entacapone inhibit only at peripheral site only

d.  entacapone inhibit both at peripheral site as well as brain but tolcapone inhibit only at brain site

ANSWERS: 1.B            2.D           3.B               4.A           5.C               6.A              7.D             8.C         9.C    10.A         11.A         12.D            13.B          14.C             15.C