CARDIOVASCULAR MCQS

1	Which of the following is lipid soluble in descending order a.digitoxin>digoxin>ouabain b.digoxin>digitoxin>ouabain c.ouabain> digitoxin>digoxin d. digitoxin>ouabain>digoxin
2	Which of the following is not true about cardiac glycoside a.they are cumulative drugs b.digitoxin have t1/2 life 28 days c.digitoxin show plasma protein binding higher as compare to the digoxin d.they have high therapeutic index
3	Losartan is a a.competitine antagonist and inverse agonist of A-II B.Non competitive antagonist and agonist of A-II C.COMPETITIVE AND  ANTAGONIST AND AGONIST OF A-II D. COMPETITIVE AGONIST AND  INVERSE AGONIST OF A-II
4	COUGH IS A SIDE EFFECT OF A.ACE INHIBITORS B.ANGIOTENSIN ANTAGONIST C.BOTH D.NONE
5	WHICH OF THE FOLLOWING DO NOT CAUSE DEGRADATION OF BRADYKININ  A.ACE INHIBITORS B.ANGIOTENSIN ANTAGONIST C.BOTH D.NONE
6.	DIGITALIS TOXICITY IS ENHANCED BY A.HYPOKALEMIA B.MYXOEDEMA C.CALCIUM D.QUINIDINE CORRECT STATEMENT I).A,B,C II)A,B,C,D III)A,B IV)C,D
7	SELECT THE VENODILATOR DRUG (DECREASE PRELOAD) A.HYDRALAZINE B.MINOXIDIL C.GLYCERYL TRINITRATE D.NIFEDIPINE
8	SELECT THE ARTERIOLAR DILATOR DRUG (DECREASE AFTERLOAD) A.NICORANDIL B.MINOXIDIL C.GLYCERYL TRINITRATE D.BOTH A AND B
9	ACE INHIBITORS AND ARB HAVE MEDIUM EFFICACY THROUGH ORAL ROUTE(MIXED DILATORS, DECREASE PRE AND AFTER LOAD) WHILE SODIUM NITROPRUSSIDE IS HIGH EFFICACY THROUGH A.ORAL B.I.V C.S.C. D.I.M.
10	SELECT THE PHOSPHODIESTERASE III INHIBITORS A.AMRINONE B.MILRINONE C.NISIRITIDE D.ALL OF THESE
11	ANTIARRYTHMIC DRUG ACT BY Na CHANNEL BLOCKING A.VERAPAMIL B.AMIODARONE C.PROCAINAMIDE D.ALL
12	IST CHOICE OF DRUG IN PAROXYMAL SUPRAVENTRICULAR TACHYCARDIA (PSVT) A.ADENOSINE B.ESMOLOL C.LIDOCAINE D.DIGOXIN
13	SELECT THE DRUG WHICH USED TO ABORT OR TERMINATE ANGINA  ATAACK A.CALCIUM CHANNEL BLOCKER B.GTN C.ISOSORBIDE DINITRATE D BOTH B AND C
14	WHICH OF THE NITRATE IS LONG ACTING BUT SUBLINGUALLY SHORT ACTING A.GTN B.NITROGLYCERINE C.ISOSORBIDE DINITRATE D.ERYTHRITYL TETRANITRATE
15	SELECT THE CCB WHICH IS LIPOPHILIC A.VERAPAMIL B.NIFEDIPINE C.DILTIAZEM D.ALL
16	Captopril produces greater fall in blood pressure in: A. Diuretic treated patients B. Patients having low plasma renin activity C. Sodium replete normotensive individuals D. Untreated CHF patients
17	Actions of bradykinin include the following except: A. Fall in blood pressure B. Cardiac depression C. Increase in capillary permeability D. Bronchoconstriction
18	Among all cardiac glycosides, digoxin is the most commonly used, because: A. It is the most potent and fastest acting glycoside B. It has the highest and most consistent oral bioavailability C. It is the longest acting and the safest glycoside D. It has intermediate plasma half life so that dose adjustments are possible every 2-3 days and toxicity abates rather rapidly after discontinuation
19	Select the most suitable antiarrhythmic drug for counteracting ventricular extrasystoles due to digoxin toxicity: A. Lignocaine B. Quinidine C. Verapamil D. Amiodarone
20	The following drug given concurrently can enhance toxicity of digoxin: A. Phenobarbitone B. Metoclopramide C. Quinidine D. Magnesium hydroxide
21	Digoxin is contraindicated in: A. Angina pectoris patients B. Ventricular tachycardia C. Hypertensive patients D. Complete heart-block
22	Higher incidence of myocardial infarction and increased mortality has been noted with the use of the following antihypertensive drug: A. Nifedipine B. Verapamil C. Diltiazem D. Lisinopril
23	Persistent dry cough may occur as a side effect of the following antihypertensive drug: A. Enalapril B. Atenolol C. Diltiazem D. Methyldopa
24	Loss of taste sensation can be a side effect of the following antihypertensive drug: A. Clonidine B. Captopril C. Verapamil D. Prazosin
25	Rebound hypertension on sudden stoppage of medication is most likely to occur with: A. Hydrochlorothiazide B. Prazosin C. Clonidine D. Lisinopril
26	The following antihypertensive drug has been found to suppress certain manifestations of morphine withdrawal syndrome and to block postoperative pain when injected intrathecally: A. Prazosin B. Clonidine C. Reserpine D. Ketanserin
27	Long-term hydralazine therapy is likely to cause: A. Gynaecomastia B. Thrombocytopenia C. Haemolytic anaemia D. Lupus erythematosus
28	The following vasodilator(s) act(s) by opening K+ channels in the vascular smooth muscle: A. Dipyridamole B. Minoxidil C. Diazoxide D. Both ‘B’ and ‘C’
29	The following antihypertensive drug tends to lower plasma renin activity: A. Clonidine B. Hydralazine C. Nifedipine D. Captopril
30	Quinidine is now used primarily for: A. Conversion of atrial fibrillation to sinus rhythm B. Control of ventricular rate in atrial flutter C. Termination of ventricular tachycardia D. Prevention of recurrences of atrial fibrillation/ ventricular tachycardia
	ANSWERS: 1.A       2.D        3.A        4.A         5.B        6.B            7.C            8.D       9.B      10.D 11.C       12.A        13.D       14.C       15.B      16.A      17.B         18.D         19.A      20.C 21.B       22.A        23.A        24.B       25.C      26.B      27.D        28.D        29.A      30.D