PHARMACOLOGY MCQS-1

1.	A diuretic that reduces insulin secretion is A) indapamide             b) furosemide            c) acetazolamide         d) amiloride	A
2.	Match the following 1.        Glucocorticoids                                          a. Aldosterone receptor antagonist 2.        Thiazides                                                      b. Metabolite of spiranolactone 3.        Canrenone                                                    c. Structure same as diazoxide 4.        Eplerenone                                                  d. Anti-inflammatory a. 1-d, 2-c, 3-b, 4-a                                                          b) 1-d, 2-a, 3-b, 4-c c.1-d, 2-b, 3-c, 4-a                                                          d) 1-a, 2-d, 3-b, 4-c	A
3.	Anaphylaxis is caused by histamine & treated by adrenaline. It is A) vasodilation & bronchoconstriction       b) vasodilation & bronchodilation C) vasoconstriction & bronchodilation     d) vasoconstriction & bronchoconstricton	A
4.	Two drugs blocks histamine, serotonin, cholinergic receptors. Identify A) cinnarizine & promethazine                    b) cinnarizine & cyprohepatadine C) promethazine & cyprohepatadine         d) terfenadine & cinnarizine	B
5.	One is not a serotonin agonist A) cisapride              b) sumatriptan         c) buspiron                  d) clozapine	D
6.	Serotonin antagonist chiefly used in vomiting is A) ondensteron         b) ketanserin                c) methylsergide    d) pizotifen	A
7.	One drug is not used in raynaud’s disease A) ginkgo                  b) reserpine                        c) ketanserin         d) risperidone	D
8.	One is not a selective cox2 inhibitor A) diclofenac            b) sulindac                  c) celecoxib      d) both a and b	D
9.	Match the following 1.        Epoprostinol                                           a. Reduces post partum hemorrhage 2.        Misoprostol                                             b. Peptic ulcer treatment 3.        Dinoprostone                                          c. Induces abortions 4.        Carboprost                                               d. Inhibits platlets aggregation A) 1-d, 2-c, 3-a, 4-b                                                           b) 1-c, 2-d, 3-a, 4-b C) 1-d, 2-b, 3-c, 4-a                                                          d) 1-a, 2-b, 3-c, 4-d	C
10.	Asthma is induced by A) histamine                b) thromboxanes               c) lecuoterines                  d) all	D
11.	Match the following 1.        Acetyl coa                                                              a. Thromboxanes 2.        Tryptophan                                                            b. 2- ethyl amine imidazole 3.        Histidine                                                                  c. Serotonin 4.        Arachadonic acid                                                   d. Cholesterol A) 1-d, 2-c, 3-b, 4-a                                                                  b) 1-a, 2-c, 3-b, 4-d C) 1-d, 2-b, 3-c, 4-a                                                                 d) 1-a, 2-b, 3-c, 4-d	A
12.	Match the following 1.        Progabide                                                                     a. Neurokinin antagonist 2.        Pergolide                                                                      b. Gastrin antagonist 3.        Proglumide                                                                       c. Dopamine agonist 4.        Vofopitant                                                                        d. Gaba agonist A) 1-d, 2-c, 3-b, 4-a                                                                b) 1-a, 2-c, 3-b, 4-d C) 1-d, 2-b, 3-c, 4-a                                                               d) 1-a, 2-b, 3-c, 4-d	A
13.	A drug useful in migraine is A) risatriptan                b) clonidine                      c) clozapine            d) both a & c	A
14.	One is not a mast cell stabilizer, identify A) kitotifen      b) pizotifen   c) disodium chromoglycate      d) nedocromil   e) pemirolast	B
15.	Match the following 1. Bismuth chelate                                                       a. Orange red urine color 2. Phenazopyridine                                                      b. Red green color blindness 3. Ethambutol                                                              c. Cherry red urine color 4. Rifampicin                                                                d. Blackening of faeces & tongue A) 1-d, 2-c, 3-b, 4-a                                                          b) 1-d, 2-b, 3-c, 4-a C) 1-d, 2-a, 3-c, 4-b                                                         d) 1-b, 2-a, 3-c, 4-d	A
16.	Match the following 1.        Ciggerete                                                                   a. Activates p450 2.        Omeperazole                                                             b. Inhibits p450 3.        Pramipaxole                                                              c. Decreases milk hormone 4.        Domperidone                                                            d. Increases milk hormone A) 1-a, 2-b, 3-d, 4-c                                                          b) 1-a, 2-b, 3-c, 4-d C) 1-b, 2-a, 3-c, 4-d                                                         d) 1-b, 2-a, 3-d, 4-c	B
17.	Arachadonic acid is chemically A) 5,8,11,14 eicosa tetraenoic acid                  b) cyclopentyl heptanoic acid C) 5,8,10,12 heptanoic acid                               d) 5,8,11,12 eicosa heptanoic acid	A
18.	Prostaglandins are the derivatives of prostanoic acid containing carbon number A) 20                             b) 25                                 c) 15                                   d) 40	A
19.	Prostaglandins also named endoperoxides are A) PGG & H              b) PGE & F                    c) PG D,E,F                   d) PGI	A
20.	Cycloxygenase & lipoxygenase needs two agents for proper working. They are 1. Oxygen                    2. Heampolymerase           3. Nitrogen            4. Heam oxygenase A) 1 & 2                      b) 1 & 4                             c) 2 & 3                     d) 2 & 4	B
21.	Oppeanaur oxidation is the characterstic feature of A) osmotic diuretics     b) spiranolactone  c) indomethacin        d) loratidine	B
22.	Phenylbutazone is metabolized in our body by an enzyme A) esterases         b) methyl transferase           c)  azoreductase       d) epoxidases	C
23.	Khellin is a bronchodilator from ammi visnaga. Chemically it is A. Flavonoid glycoside b) diterpenoid      c) furano coumarin         d) coumarin only	C
24.	Nitric oxide releasing compounds are successful in combination with A) diuretics             b) nsaid’s               c) h1 blockers               d) h2 blockers	B
25.	An anti kaliuretic agent is A.ethacrynic acid  b) spiranolactone   c) triamterene    d) furosemide   e) both b & c	E
26.	Histamine is mainly involved in which type of allergic reactions? A.type 1  b. Type 2 c. Type 3 d. Type 4	A
27.	Which of the following is antihistaminic, anticholinergic and 5ht antagonist A.cinnarizine            b. Cyprohetadine         c. Mepyramine        d.both a & b	A
28.	N-acetylcysteine is used in the poisoning of which nsaid A.Aspirin       b.indomethcin       c. Paracetamol      d. Sulindac	C
29.	Paracetamol is detoxified by A.glucuronide conjugation   b. Glutathione conjugation C.glycine conjugation   d.sulphate conjugation	B
30.	Which of the following is prodrug & converted to sulfide active metabolite A.Phenacetin       b. Sulindac       c. Indomethacin         d. Nabumetone	B
31.	Lefluomide an anti rheumatoid drug inhibits A.Thymidylate synthtase       b.aldehyde dehydrogenase C..nuclear receptor activation     d. Dihydro-orotate dehydrogenase	A
32.	Identify the false statement about allopurinol a.        Allopurinol is an analogue of hypoxanthine b.        Allopurinol is converted to alloxanthine by xanthine oxidase c.        Allopurinol increases uric acid excretion d.        Used as prophylactic as the drug of choice in the long-term treatment of gout, but it is ineffective in the treatment of an acute attack and may even exacerbate the inflammation.	C
33.	Identify the drug choice for acute gout attack A.Allopurinol      b.probenecid    c. Colchicine    d. Diclofenac & colchicine	C
34.	All of the following are the roles of histamine except a.        It increases appetite                 b.it produces sensation of itch b.        Causes bronchoconstriction    d.increases gastric acid secretion	A
35.	Antihistaminic used to increase appetite in underweight children is A.Cetrizine    b.loratidine      c.loxatidine    d. Buclizine	D