gpatadda: PHARMACOLOGY MCQS

1.	Cetrizine is a active metabolite of A.Hydroxyzine b.promethazine c.cimetidine d. Cinnarizine	A
2.	Eicosanoids includes A.Prostaglandins b. Leukotrienes c. Thromboxane d.all	D
3.	In ltb₄ the subscript ‘4’ indicates a.No. Of double bonds b.no. Of conjugated doubles bonds c.C..no. Of alkyl substitutions d. No. Of halogens	B
4.	Platelets primarily synthesize a.TXA₂ b. PGI₂c. LTB_{4 d.}Histamine	A
5.	Endothelium mainly generates a.PGG₂b._.PGI_c.PAF d. PGF2_α	B
6.	All NSAIDS are reversible inhibitors of cyclo oxygenase except a.Aspirin b.indomethacin c. Celecoxib d. Paracetamol	A
7.	N-acetyl-p-benzoquinoneimine is highly reactive heapatotoxic metabolite is of a.Aspirin b.indomethacin c. Paracetamol d.ibuprofen	C
8.	All of the following have arrhythmic potential by prolonging qtc interval except a.Loratadine b.astemizole c.terfenadine d.ebastine	C
9.	Which of the following anti gout drug also inhibits platelet aggregation a.Colchicine b.sulfinpyrazone c. Diclofenac d.allopurinol	B
10.	Which of the following drug have local anesthetic effect also a.Promethazine b.mepyramine c.diphenhydramine d.loratidine	A
11.	Which of the following is not a vasodilator a.PGE₂b. PGI₂c.PGD₂d. PGF_2α	D
12.	Serotonin is biosynthesized from a.Tryptophan b.tyrosine c. Histidine d.phenylalanine	A
13.	Histamine is biosynthesized from decarboxylation of a.Tryptophan b.tyrosine c. Histidine d.phenylalanine	C
14.	Nsaids can inhibit the production of all except a.PGI₂b cyclic endoperoxides c. TXA₂d. Leukotrienes	D
15.	NSAID used for ocular inflammation a.Ibuprofen b. Piroxicam c.nimesulide d.flurbiprofen	D
16.	Which of the following hormone is released from anterior pituitary gland a.Parathormone b.thyroid stimulating hormone c.vasopressin d.somatostatin	B
17.	Somatotatin is released from pancreas as well as from a.Hypothalamus b.anterior pituitary gland posterior pituitary gland d. All	A
18.	Which hormone help in adaptation to stress a.Adrenaline b. Glucocorticoid c.both d.parathormone	C
19.	Which of the following help in maintenance of calcium balance a.Vitamin-d b.parathormone c.calcitonin d.all	D
20.	Which of the following hormone is also released from placenta a.estrogen b.prolactin c.chorionic gonadotrophin d.all	D
21.	Match following 1. Dwarfism a. Growth hormone deficiency in childs 2. Acromegaly b. Growth hormone overproduction in adults 3. Gignatism c. Growth hormone overproduction in childs 4. Addisons disease d. Hyposecretion of sex hormone Select a.1-b, 2-a,3-c,4-d b.1-a,2-b,3-c,4-d c..1-a,2-b,3-d,4-c d.1-a,2-c,3-b,4-d	B
22.	Match the following 1. Cushing syndrome a. Hypersecretion of corticosteroid hormone 2. Cretinism b. Hyposecretion of thyroid hormone in childs 3. Myxoedema c. Hyposecretion of thyroid hormone in adults 4. Graves disease d. Autimmune disease, igg antibodies form against tsh receptor Select a.1-a,2-b,3-c,4-d b.1-a,2-c,3-b,4-d c.1-d,2-b,3-c,4-a d.1-d,2-c,3-b,4-d	A
23.	Which preparation is used in growth hormone deficiency (dwarfism) A.somatropin b.somatrem c.somatostatin d.both a and b e. All	D
24.	Match following 1.octreotide synthetic and used in acromegaly 2. Cabergoline d2 agonist 3.nafareline long acting gnrh agonist Select a.1-a,2-b,3-c b. 1-b,2-a,3-c c.1-c,2-b,3-a d.1-a,2-c,3-b	A
25.	Propylthiouracil inhibit peripheral conversion of t4 to t3 by inhibiting a.d1 b.d2 c.both d.not inhibit peripheral conversion	A
26.	Safe antithyroid therapy in pregnancy a.radioactive iodine b.propylthiouracil c..carbimazol d.all	B

1.	A diuretic that reduces insulin secretion is A) indapamide b) furosemide c) acetazolamide d) amiloride	A
2.	Match the following 1. Glucocorticoids a. Aldosterone receptor antagonist 2. Thiazides b. Metabolite of spiranolactone 3. Canrenone c. Structure same as diazoxide 4. Eplerenone d. Anti-inflammatory a. 1-d, 2-c, 3-b, 4-a b) 1-d, 2-a, 3-b, 4-c c.1-d, 2-b, 3-c, 4-a d) 1-a, 2-d, 3-b, 4-c	A
3.	Anaphylaxis is caused by histamine & treated by adrenaline. It is A) vasodilation & bronchoconstriction b) vasodilation & bronchodilation C) vasoconstriction & bronchodilation d) vasoconstriction & bronchoconstricton	A
4.	Two drugs blocks histamine, serotonin, cholinergic receptors. Identify A) cinnarizine & promethazine b) cinnarizine & cyprohepatadine C) promethazine & cyprohepatadine d) terfenadine & cinnarizine	B
5.	One is not a serotonin agonist A) cisapride b) sumatriptan c) buspiron d) clozapine	D
6.	Serotonin antagonist chiefly used in vomiting is A) ondensteron b) ketanserin c) methylsergide d) pizotifen	A
7.	One drug is not used in raynaud’s disease A) ginkgo b) reserpine c) ketanserin d) risperidone	D
8.	One is not a selective cox2 inhibitor A) diclofenac b) sulindac c) celecoxib d) both a and b	D
9.	Match the following 1. Epoprostinol a. Reduces post partum hemorrhage 2. Misoprostol b. Peptic ulcer treatment 3. Dinoprostone c. Induces abortions 4. Carboprost d. Inhibits platlets aggregation A) 1-d, 2-c, 3-a, 4-b b) 1-c, 2-d, 3-a, 4-b C) 1-d, 2-b, 3-c, 4-a d) 1-a, 2-b, 3-c, 4-d	C
10.	Asthma is induced by A) histamine b) thromboxanes c) lecuoterines d) all	D
11.	Match the following 1. Acetyl coa a. Thromboxanes 2. Tryptophan b. 2- ethyl amine imidazole 3. Histidine c. Serotonin 4. Arachadonic acid d. Cholesterol A) 1-d, 2-c, 3-b, 4-a b) 1-a, 2-c, 3-b, 4-d C) 1-d, 2-b, 3-c, 4-a d) 1-a, 2-b, 3-c, 4-d	A
12.	Match the following 1. Progabide a. Neurokinin antagonist 2. Pergolide b. Gastrin antagonist 3. Proglumide c. Dopamine agonist 4. Vofopitant d. Gaba agonist A) 1-d, 2-c, 3-b, 4-a b) 1-a, 2-c, 3-b, 4-d C) 1-d, 2-b, 3-c, 4-a d) 1-a, 2-b, 3-c, 4-d	A
13.	A drug useful in migraine is A) risatriptan b) clonidine c) clozapine d) both a & c	A
14.	One is not a mast cell stabilizer, identify A) kitotifen b) pizotifen c) disodium chromoglycate d) nedocromil e) pemirolast	B
15.	Match the following 1. Bismuth chelate a. Orange red urine color 2. Phenazopyridine b. Red green color blindness 3. Ethambutol c. Cherry red urine color 4. Rifampicin d. Blackening of faeces & tongue A) 1-d, 2-c, 3-b, 4-a b) 1-d, 2-b, 3-c, 4-a C) 1-d, 2-a, 3-c, 4-b d) 1-b, 2-a, 3-c, 4-d	A
16.	Match the following 1. Ciggerete a. Activates p450 2. Omeperazole b. Inhibits p450 3. Pramipaxole c. Decreases milk hormone 4. Domperidone d. Increases milk hormone A) 1-a, 2-b, 3-d, 4-c b) 1-a, 2-b, 3-c, 4-d C) 1-b, 2-a, 3-c, 4-d d) 1-b, 2-a, 3-d, 4-c	B
17.	Arachadonic acid is chemically A) 5,8,11,14 eicosa tetraenoic acid b) cyclopentyl heptanoic acid C) 5,8,10,12 heptanoic acid d) 5,8,11,12 eicosa heptanoic acid	A
18.	Prostaglandins are the derivatives of prostanoic acid containing carbon number A) 20 b) 25 c) 15 d) 40	A
19.	Prostaglandins also named endoperoxides are A) PGG & H b) PGE & F c) PG D,E,F d) PGI	A
20.	Cycloxygenase & lipoxygenase needs two agents for proper working. They are 1. Oxygen 2. Heampolymerase 3. Nitrogen 4. Heam oxygenase A) 1 & 2 b) 1 & 4 c) 2 & 3 d) 2 & 4	B
21.	Oppeanaur oxidation is the characterstic feature of A) osmotic diuretics b) spiranolactone c) indomethacin d) loratidine	B
22.	Phenylbutazone is metabolized in our body by an enzyme A) esterases b) methyl transferase c) azoreductase d) epoxidases	C
23.	Khellin is a bronchodilator from ammi visnaga. Chemically it is A. Flavonoid glycoside b) diterpenoid c) furano coumarin d) coumarin only	C
24.	Nitric oxide releasing compounds are successful in combination with A) diuretics b) nsaid’s c) h1 blockers d) h2 blockers	B
25.	An anti kaliuretic agent is A.ethacrynic acid b) spiranolactone c) triamterene d) furosemide e) both b & c	E
26.	Histamine is mainly involved in which type of allergic reactions? A.type 1 b. Type 2 c. Type 3 d. Type 4	A
27.	Which of the following is antihistaminic, anticholinergic and 5ht antagonist A.cinnarizine b. Cyprohetadine c. Mepyramine d.both a & b	A
28.	N-acetylcysteine is used in the poisoning of which nsaid A.Aspirin b.indomethcin c. Paracetamol d. Sulindac	C
29.	Paracetamol is detoxified by A.glucuronide conjugation b. Glutathione conjugation C.glycine conjugation d.sulphate conjugation	B
30.	Which of the following is prodrug & converted to sulfide active metabolite A.Phenacetin b. Sulindac c. Indomethacin d. Nabumetone	B
31.	Lefluomide an anti rheumatoid drug inhibits A.Thymidylate synthtase b.aldehyde dehydrogenase C..nuclear receptor activation d. Dihydro-orotate dehydrogenase	A
32.	Identify the false statement about allopurinol a. Allopurinol is an analogue of hypoxanthine b. Allopurinol is converted to alloxanthine by xanthine oxidase c. Allopurinol increases uric acid excretion d. Used as prophylactic as the drug of choice in the long-term treatment of gout, but it is ineffective in the treatment of an acute attack and may even exacerbate the inflammation.	C
33.	Identify the drug choice for acute gout attack A.Allopurinol b.probenecid c. Colchicine d. Diclofenac & colchicine	C
34.	All of the following are the roles of histamine except a. It increases appetite b.it produces sensation of itch b. Causes bronchoconstriction d.increases gastric acid secretion	A
35.	Antihistaminic used to increase appetite in underweight children is A.Cetrizine b.loratidine c.loxatidine d. Buclizine	D

gpatadda

Tuesday, 7 February 2017

PHARMACOLOGY MCQS-2

PHARMACOLOGY MCQS-1