PHARMACEUTICS AND PHARMACOLOGY MCQS

1.	About LAL test which  is true: a.        Limulus Amoebocyte Lysate test or bacterial Endotoxin test for the validation of depyrogenation process. b.        Reagent  used - LAL reagent (limulus Polyphemus) c.        Reaction occur  - In presence of Endotoxin a firm gel is formed within 60 min when incubated at 370 C. d.        All above	D
2.	Sterilization                              Mechanism a.        Heat       (1) Does not destroy(Removes microorganisms) b.        Gaseous (2) Ionization of nucleic acids c.        Radiation (3)  Alkylation d.        Filtration (4) Destroys bacterial endotoxins (a)   a-1,b-2,c-3,d-4    (b) a-2,b-3,c-1,d-4  (c)   a-4,b-3,c-2,d-1     (d) a-3,b-4,c-2,d-1	C
3.	Forms of water that are suitable for use in parenteral preparations include I. purified water USP. II. water for injection USP. iii Sterile water for injection USP  A if I only is correct B if III only is correct C if I and II are correct D if II and III are correct E if I, II, and III are correct	D
4.	Rubbing or grinding a substance in a mortar that has a rough inner surface A trituration B spatulation C levigation D pulverization by intervention E tumbling	A
5.	A drug which produces different actions when administered through different routes is: A. Barbiturate         B. Minoxidil            C. Magnesium sulphate              D. Nitroglycerine	C
6.	which adverse drug effect is more common in children than in adults: a. isoniazid induced neuropathy             b. chlorpromazine induced muscle dystonia c. digoxin induced cardiac arrhythmia    d. penicillin hypersensitivity	b
7.	therapeutic window phenomenon means: a. hypersensitivity                         b. desensitization c. when therapeutic effects decline both below and above a narrow range of doses d. nonreceptor mediated action	c
8.	Which of the following is example of chemical antagonism  a. histamine antagonise effect of adrenaline b. the antidotal action of sodium nitrite in cyanide poisoning c. adsorption of poison on charcoal d.all	b
9.	which adverse drug effect is more common in children than in adults: a. isoniazid induced neuropathy             b. chlorpromazine induced muscle dystonia c. digoxin induced cardiac arrhythmia    d. penicillin hypersensitivity	b
10.	Select the adverse effect which is observed in genetically abnormal person: a. cyclophosphamide cause cystitis                         b. daunorubicin cause cardiomyopathy c. metoclopramide induced muscle dystonia          d. primaquine induced massive aemolysis	d
11.	match 1.drugs producing allergic reactions  known as             a.haptenes 2.type b (unpredictable) adverse drug reaction is:         b.  idiosyncrasy 3.an undesirable effect that occurs at therapeutic          c.side effect doses and can be predicted from its pharmacological actions is known as 4.placebo is a                                                                   d.dummy medication                                                                                         e. toxic effect                                                                                         f. complete antigencorrect a.1-a, 2-b, 3-e,4-d       b.1-f, 2-b 3-e, 4-d       c.1-f, 2-b, 3-c,4-d      d.1-a, 2-b,3-c, 4-d	D
12.	Type of hypersensitivity which is detected by intradermal drug sensitivity tests: a. type I             b. type ii          c. type iii                   d. type iv	a
13.	During pregnancy which is the most vulnerable period that cause the foetal malformations due to drugs is: a. 18-54 days of gestation    b. 55-85 days of gestation     c. second trimester   d. 36 weeks onwards	a
14.	functional proteins that are target of drug action i.enzymes            ii.transporters             iii.ion channels          iv.receptors correct a.i,ii,iii              b.ii,iv             c.i,ii                        d.i,ii,iii,iv	d
15.	which of the following drug is a competitive inhibitor of enzyme but non equilibrium type a.physostigmine compete with acetycholine for cholinesterase b.sulfonamide compete with paba for bacterial folate synthase c.allopurinol compete with hypoxanthenes for xanthine oxidase d.organophosphate compete with acetylcholine for cholinestrase	d
16.	which of the following drug is not a non competitive inhibitor of enzyme a.acetazolamide inhibit carbonic anhydrase              b.disulfiram inhibit aldehyde dehydrogenase c.digoxin inhibit na k atpase                                     d captopril inhibit ace enzyme	d
17.	select the drug act through  ion channel a.ethosuximide         b.amiloride                c.both a nd b                  d.none of these	c
18.	select the drug act through transporters i.fluoxetine                    ii.phenytoin                  iii.furosemide                     iv.desipramine correct a.i,ii,iii               b.i,iii,iv                        c.ii,iii,iv                      d.i,ii,iii,iv	b
19.	select the wrong statement a.competitive antagonist have high affinity  and high intrinsic activity b.partial agonist have affinity and sub maximal intrinsic activity c.inverse agonist have affinity but intrinsic activity with a minus sign d.agonist have both high affinity and maximal intrinsic activity	a
20.	In clinical trial, in phase -1, persons are commonly involved a.healthy person      b.patient     c .in case of hiv and cancer study –involvehealthy person	a
21.	No. of patient involved in phase-3 of clinical trials a.20-40     b.100-400      c.500-3000    d. 5000-8000	c
22.	which preparation should be avoided through i.v. route a.aq. solution             b.aq suspension               c.suspensions            d.both b and c	d
23.	a drug easily cross git barrier if a.unionized and hydrophilic                              b.ionized and hydrophilic    c.unionized and lipophilic                                 d.ionized and hydrophilic	c