CENTRAL NERVOUS SYSTEM MCQS-1

1. Match the following

1. Pramipaxole                                                           a. Dopamine precursor
2. Lysuride                                                                 b. Partial D1 agonist
3. Bromcryptine                                                         c. D1 & D2 agonist
4. Levodopa                                                               d. Pure D2 agonist
5. Domperidone                                                         e. Dopamine antagonist

      a) 1-d, 2-b, 3-c, 4-a, 5-e                                               b) 1-c, 2-d, 3-b, 4-a, 5-e

C) 1-d, 2-c, 3-b, 4-a, 5-e                                              d) 1-d, 2-a, 3-c, 4-b, 5-e

2. a CNS stimulant usually given in carbon monoxide poisoning along with diazepam is

A) doxapram                  b) niketamide             c) picrotoxin               d) glutithimide

3. The drug of choice in ADHD is

A) picrotoxin                 b) flumazenil              c) dexamphetamine    d) doxapram

4. A selective MAO B inhibitor is

A) deprenyl                    b) tranylcypromine    c) phenelzine               d) isocarboxazid

5. The drug of choice in benzodiazopene poisoning is

A) picrotoxin                 b) flumazenil              c) naloxone                  d) gabapentin

6. Identify the drug blocking GABA receptor

A) gabapentin                b) picrotoxin               c) flumazenil               d) both b & c

7. Disulfiram is the drug used to stop alcohol habit. It act by inhibiting

A) alcohol dehydrogenase  b) aldehyde dehydrogense   c) both      d) acid dehydrogenase

8. Methylxanthines are used as CNS stimulants. act by

A) block adenosine receptors      b) inhibiting phosphodiesterase   c) increasing calcium ions                                                         d) increasing cAMP & cGMP     e) all

9. An only local anesthetic causing vasoconstriction is

A) procaine                      b) benzocaine                   c) bupivacaine                d) cocaine

10. Match the following

1. Mania (bipolar)                                                          a Lithium
2. Bed wetting treatment                                                b. Disulfiram & propanolol
3. Alcohol withdrawl                                                      c. Imipramine

                                                                      Lithium ions

      a) 1-c, 2-a, 3-b                                                         b) 1-a, 2-b, 3-c

C) 1-a, 2-c, 3-b                                                        d) 1-c, 2-b, 3-a

11. Match the following

1. Cocaine                                                                     a. GABA reuptake inhibitor
2. Ketamine                                                                   b. Dopamine reuptake inhibitor
3. Imipramine                                                                c. NA reuptake inhibitor
4. Tiagabine                                                                  d. NA & serotonin reuptake inhibitor

      a) 1-c, 2-b, 3-d, 4-a                                                          b) 1-c, 2-d, 3-b, 4-a

C) 1-d, 2-c, 3-b, 4-a                                                         d) 1-a, 2-b, 3-c, 4-d

12. Selective serotonin reuptake inhibitor is

A) phenelzine               b) pergyline                  c) paroxetine               d) imipramine

13. Match the following

1. MAO A inhibitor                                                        a. Valproic acid
2. MAO B inhibitor                                                         b. Tolcapone
3. COMT inhibitor                                                          c. Isocarboxacid
4. GABA metabolizing enz inhibitor                              d. Selegine

      a) 1-c, 2-b, 3-d, 4-a                                                           b) 1-c, 2-d, 3-b, 4-a

C) 1-d, 2-c, 3-b, 4-a                                                          d) 1-a, 2-b, 3-c, 4-d

14. All drugs results in parkinsonism except

A) haloperidol             b) thiothixene             c) fluphenazine              d) lysuride

15. Match the following

1. Naloxone                                                                    a. k agonist, μ, δ antagonist                                                   
2. Loperamide & fentanyl                                              b. μ agonist
3. Morphine & heroin                                                    c. μ, k agonist
4. Buprenorphine & methadone                                    d. k agonist
5. Pentazocine                                                                e. Antagonist of all

      a) 1-d, 2-b, 3-c, 4-a, 5-e                                                   b) 1-c, 2-d, 3-b, 4-a, 5-e

C) 1-e, 2-d, 3-c, 4-b, 5-a                                                  d) 1-a, 2-b, 3-c, 4-d, 5-e

ANSWERS: 1. C               2.B              3.C               4.A                5.B            6.D           7.B                  8.E             9.D       10.C              11.A           12.C              13.B              14.D        15.C