CNS Neurotransmitters BASIC

NEUROTANSMITTERS	NATURE	RECEPTOR	OTHERS
1.Acetylcholine	Excitatory as well as inhibitory	Muscarinic- M1,M2,M3,M4 Nicotinic- NM, NN	M1,M2,M3,M4-GPCR- via secondary messengers M1,M3-IP3-DAG Pathway (Gq) M2,M4-cAMP pathway (Gi,Go) NM, NN -Ion channel-direct action
2.Biogenic amines
A. Nor epinephrine (feel good neurotansmitter) It gives people bursts of energy. Basically, it makes the body feel as good and energized as the body ever can. Meanwhile, noradrenaline sends out brain signals which increase focus. The combination of dopamine and these two (adrenaline and nor adrenaline) leaves people feeling alert and happy.	Excitatory as well as inhibitory	α- α1, α2 β- β1, β2, β3	α1, α2, β1, β2, β3- GPCR via secondary messengers α1- IP3-DAG pathway (Gq) α2-cAMP pathway  (Gi, Go) β1, β2, β3-cAMP pathway (Gs)
B.Dopamine (feel good neurotansmitter) Dopamine is a neurotransmitter that keeps a stressed body feeling good.	Excitatory as well as inhibitory (mainly inhibitory)	D1, D2,D3,D4,D5	D1-5 - GPCR – via secondary messengers D1- cAMP pathway (Gs) D2- cAMP pathway (Gi,Go)
C.  Serotonin (5-HT) (feel good neurotransmitter) People who suffer from depression do have lower levels of serotonin.	Excitatory as well as inhibitory (mainly inhibitory)	5-HT1, 5-HT2, 5-HT3, 5-HT4	5-HT1, 5-HT2, 5-HT4 -GPCR-via secondary messengers 5-HT1- cAMP pathway (Gi,Go) 5-HT2- IP3-DAG pathway (Gq) 5-HT3- Ion channel receptor 5-HT4- cAMP pathway (Gs)
D.Histamine	Excitatory as well as inhibitory	H1,H2,H3	H1,H2,H3-GPCR-via secondary messengers H1-IP3-DAG pathway (Gq) H2- cAMP pathway (Gs) H3- cAMP pathway (Gi,Go)
3.Purines
A.ATP	Excitatory as well as inhibitory	P1-
B.Adenosine	Excitatory as well as inhibitory	A1,A2	A1,A2- GPCR via secondary messengers A1- cAMP pathway (Gi, Go) A2- cAMP pathway (Gs)
4.Amino acids
A.GABA (gama amino butyric acid)	Inhibitory	GABAA,  GABAB	GABAA-ion channel GABAB-GPCR-via secondary messengers GABAA- via ion channel GABAB-cAMP pathway (Gi,Go)
B.Glutamate	Excitatory	NMDA, AMPA, Kainate-ion channel	Via ion channel
C.Glycine	Inhibitory	Ion channel receptor	via  ion channel
5.Peptides
A.Bradykinin		B1,B2	B1, B2 – GPCR - via secondary messengers B1-IP3-DAG pathway (Gq,Gi) B2- IP3-DAG pathway-(Gq, Gi)
B.Endorphins: Endorphins has been shown to increase happiness) endorphins, which mostly block pain and bring in a little euphoria, endorphins are present in all over the body	Inhibitory	Mu-µ1. µ2 Kappa- κ1, κ2, κ3 delta-δ1, δ2	Mu, kappa, delta- GPCR-via secondary messengers Mu-cAMP pathway (Gi,Go) Delta- cAMP pathway (Gi, Go) Kappa- Go
C.Somatostatin	Inhibitory	SST1,SST2,SST3,SST4,SST5
D.Cholecystokinin		CCKa, CCKb	CCKa  CCKb –GPCR via secondary messengers
E.Substance-P/Tachykinins  Substance P and the NK1 receptor found in brain regions that are specific to regulating emotion (hypothalamus, amygdala, and the periaqueductal gray). They are found in close association with serotonin(5-HT) and neurons containing norepinephrine that are targeted by the currently used antidepressant drugs	Excitatory	NK1, NK2, NK3	NK1, NK2, NK3–GPCR via secondary messengers NK1, NK2, NK3-IP3-DAG pathway and cAMP pathway (Gs) (NK-neurokinins)
F.Tachykinins The tachykinin receptor 1 (TACR1) also known as neurokinin 1 receptor (NK1R) or substance P receptor (SPR) is a G protein coupled receptor found in the central nervous system and peripheral nervous system.	Excitatory	GPCR
GABA,Glycine are inhibitory in nature Fast channels ()