CNS MCQS-2

1	Match the following: 1.     Pramipaxole                                                           a. Gaba reuptake inhibitor 2.     Lysuride                                                                 b. Partial d1 agonist 3.     Bromcryptine                                                         c. D1 & d2 agonist 4.     Tiagabine                                                               d. Pure d2 agonist A) 1-d, 2-b, 3-c, 4-a                                           b) 1-c, 2-d, 3-b, 4-a C) 1-d, 2-c, 3-b, 4-a                                           d) 1-d, 2-a, 3-c, 4-b	C
2	CNS  stimulant usually given in carbon monoxide poisoning along with diazepam is: A) niketamide                  b) flumazenil           c) picrotoxin               d) domperidone	A
3	Drug of choice in attention deficit hyperactivity disorder (ADHD) is: A) niketamide                 b) flumazenil              c) dexamphetamine    d) doxapram	C
4	Methylxanthines which are used as CNS stimulants, act by: A) inhibiting phosphodiesterase   b) block adenosine receptors C) increasing calcium ions             d) increasing camp & cgmp     e) all of these	E
5	Match the following: 1.     Cocaine                                                    a. Dopamine precursor 2.     Ketamine                                                  b. Dopamine reuptake inhibitor 3.     Imipramine                                               c. Na reuptake inhibitor 4.     Levodopa                                                  d. Na & serotonin reuptake inhibitor A) 1-c, 2-b, 3-d, 4-a                                                          b) 1-c, 2-d, 3-b, 4-a C) 1-d, 2-c, 3-b, 4-a                                                         d) 1-a, 2-b, 3-c, 4-d	A
6	Selective serotonin reuptake inhibitor is: A) reboxetine               b) clorgyline                 c) paroxetine               d) imipramine	C
7	Mianserin, is an antidepressant. Select true: A.it inhibit NA, 5-HT uptake B.block presynaptic alpha-2 receptor in cns C.decrease release of noradrenaline by inhibitng alpha-2 receptor in brain D.it belongs to tricyclic antidepressnat category	B
8	Match the following: 1.     MAO A inhibitor                                                       a. Valproic acid 2.     MAO B inhibitor                                                       b. Tolcapone 3.     COMT inhibitor                                                        c. Clorgyline 4.     GABA metabolizing enz inhibitor                              d. Selegine A) 1-c, 2-b, 3-d, 4-a                                                           b) 1-c, 2-d, 3-b, 4-a C) 1-d, 2-c, 3-b, 4-a                                                          d) 1-a, 2-b, 3-c, 4-d	B
9	All drugs results in Parkinsonism except: A) haloperidol             b) triflupromazine            c) lysuride        d) fluphenazine	C
10	Select true: A.    Haloperidol is preferred drug in acute schizophernia B.    Prolactin release is inhibited by dopamine agonist C.    Vigabatrin inhibit gaba-transaminase D.    All	D
11	Match the following: 1.     Naloxone                                                            a. k agonist, μ, δ antagonist 2.     Fentanyl                                                             b. m agonist 3.     Morphine                                                            c. m, k agonist 4.     Buprenorphine & methadone                              d. k agonist 5.     Pentazocine                                                         e. Antagonist of all A) 1-d, 2-b, 3-c, 4-a, 5-e                                                   b) 1-c, 2-d, 3-b, 4-a, 5-e C) 1-e, 2-d, 3-c, 4-b, 5-a                                                  d) 1-a, 2-b, 3-c, 4-d, 5-e	C
12	Methadone is: A)  k agonist               b)  μ agonist            c) μ antagonist      d) k antagonist	B
13	All antiepileptic drugs blocks sodium channel except: a.Phenytoin         b) carbamazepine     c) ethosuximide                 d) valproic acid	C
14	A vitamin that increases peripheral metabolism of levodopa is: a.biotin                  b) pyridoxine           c) riboflavin                        d) vitamin D	B
15	Drug used in treatment of Parkinsonism: A. L-dopa      b.selegeline    c.amantadine         d.all	D
16	Which of the following drug is commonly used in prophylaxis of migraine: A.ergotamine      b.methysergide       c.sumatriptan          d.propranolol	D
17	Which antiepileptic drug is not  used for Absence Seizure: Phenytoin   b.ethosuximide      c.valproic acid        d.clonazepam	A
18	Spina bifida and neural tube defect caused to foetus by which antiepileptic drug A phenytoin    b ethosuximide    c valproic acid       d.clonazepam	C
19	Which  antiepileptic drug act by inhibiting ‘T’ type calcium current A.ethosuximide    b.topiramate      c.phenytoin       d.all of these	A
20	COMT inhibitor A.bromocriptine    b.ropinirole       c.entcapone       d.amantadine	C
21	Carbidopa  inhibit A.decarboxylase at perpheral site    b.decarboxylase at cns site C.both of these      d. Highly lipophilic so inhibit decarboxylase at peripheral site majorly but minorly act at peripheral site also	A
22	Which is not true about Bromocriptine A.d2 receptor antagonist                   b.d1 receptor antagonist  c.d2 receptor agonist                        d.d1 receptor partial agonist	A
23	Which of the following is a ergot derivative A.ropinirole   b.pramipexole     c carbidopa      d bromocriptine	D
24	Which anti parkinsonian drug is approved for ‘restless leg syndrome’ A.selegeline   b.bromocriptine   c.ropinirole      d.carbidopa	C
25	Entacapone and tolcapone inhibit the ‘COMT’ at A.both inhibit at peripheral site as well as brain B.tolcapone inhibit both at peripheral site as well as brain but entacapone inhibit only at brain site only C. Tolcapone inhibit both at peripheral site as well as brain but entacapone inhibit only at peripheral site only D.  Entacapone inhibit both at peripheral site as well as brain but tolcapone inhibit only at brain site	C
26	Which of the following anticholinergic drug used in parkinsonism treatment A.benzhexol      b.bispyridine     c.benzathiazole       d.triptyline	A
27	Which of the following show analgesic activity A.thebaine    b.noscapine      c.both        d.none	D
28	Which opioid is semisynthetic A.codeine     b.heroin      c.pethidine         d.all	B
29	Codeine is A.as analgesic more potent than morphine but as cough suppressant less potent than morphine B.as analgesic less potent than morphine, but as cough suppressant more potent than morphine C. As analgesic and cough suppressant less potent than morphine D.as analgesic and  cough suppressant more potent than morphine	B
30	Which opioid is used as anasthetic A.ketamine     b.pethidine       c.fentanyl      d.all	C