ANTI MALARIAL AND ANTI CANCER MCQS

1	select the 8-aminoquinolones a.primaquine     b.amodiaquine    c.piperquine    d.all of these	a
2	which species of plasmodium(malaria) is most dangerous a.p.falciparum       b.p.vivax     c.p.malariae    d.p.ovale
3	quartan malaria is caused by a.p.falciparum       b.p.vivax     c.p.malariae    d.p.ovale	a
4	which of the following is effective against exo erythrocytic stage a.chloroquine    b.primaquine    c.proguanil    d.mefloquine	b
5	select the fastest acting antimalarial drug a.chloroquine     b.artemisinin    c.proguanil    d.all of these	b
6	select the antimalarial which is effective against gametes of p.vivax a.chloroquine    b.quinine     c.primaquine     d.all of these	d
7	select the antimalarial which is effective against pre erythrocytic stage of p.falciparum a.proguanil   b.primaquine   c.both of these  d.none of these	c
8	chloroquine side effect a.loss of vision due to retinal damage b.loss of hearing and graying of hair c.arrythmia                          d.all of these	d
9	quinine used as antimalarial drug,which form a.levo    b.dextro    c.meso   d.both a and b	a
10	ringing in ears is caused by a.quinine    b.chloroquine   c.both of these     d.none of these	a
11	passage of dark urine is side effect of which antimalarial drug a.pyrimethamine    b.primaquine     c.proguanil    d.both b and c	b
12	artemisinin is a.monoterpenes  b.sesquiterpene  c.diterpene   d. none	b
13	which derivative of artimisinin is soluble in water a.artemether    b.artesunate      c.both    d.none	b
14	atovaquone(antimalarial) is a.synthetic   b.semi synthetic    c.natural    d.both a and c	a
15	which of the following is luminal amoebicides a.metronidazole     b.emetine    c.chloroquine    d.diloxanide furoat	d
16	which of the following is used only for extraintestinal amoebiasis a.metronidazole    b.emetine     c.chloroquine   d.nitazoxanide	c
17	metronidazole is selectively toxic for a.anaerobic    b.aerobic      c.both of these    d.facultative	a
18	which of the following drug have endoperoxide bridge a.chloroquine   b.artimisinin    c.primaquine    d.emetine	b
19	ion which play key role in cell function a.ca    b.k    c.na    d.cl	a
20	chloroquine starts to deposit due to high affinity for (deposit) a.melanin    b.retina     c.both of these     d.teeth	c
21	cystitis is side effect of cyclophosphamide,,it can be blocked by using a.mesna     b.acetylcysteine      c.either a or b      d.none of these	c
22	toxicity of methtrexate can be overcome by a.folic acid      b.folinic acid      c.both of these      d.none of these	b
23	for contolling cytotoxic drug induced vomiting, preferred antivomiting drug is a.metoclopramide        b.ondansetron     c.dexamethasone    d.lorazepam	b
24	select the cell cycle specific anticancer drug a.cyclophosphhamide    b.etoposide     c.procarbazine      d.all of these	b
25	vincristine is a cell cycle specific drug, it act on which phase a.g1   b.m   c.g2      d.s	b
26	antimetabolites act on which phase a.g1   b.m   c.g2      d.s	d
27	major side effect of doxorubicin/daunorubicin a.neuropathy  b.cardiotoxicity    c.both of these   d.cystitis	b
28	prominent side effect of vincristine a.neuropathy     b.cardiotoxicity    c.both of these    d.cystitis	a
29	taxane is obtained from a.bark    b.root            c.leaves                d.stem	a
30	taxane are approved for a.ovarian cancer  b.breast cancer   c.both of these         d.none of these	c
31	vincristine act by a.enhancing polymerisation of tubulin protein b.by preventing polymerisation of tubulin c.both of these                    d.any of the above	b
32	etoposide used as anticancer drug,it is a.natural       b.semi-synthetic     c.synthetic    d.both b and c	b
33	topotecan and irinotecan(semi synthetic) are obtained from a chinese tree, they act by inhibiting function of enzyme a.topoisomerase –i              b.topoisomerase-ii c.dna gyrase                        d.all of these	a
34	l –asparginase is a anticancer drug,it act by a. inhibiting l-asparagine synthase b. by inhibiting l –asparginase which convert l-asparagine to     l-aspartic acid c. . by inhibiting l –asparginase which convert l-aspartic acid to l-asparagine                     d.both a and b	b
35	imatinib  act by inhibiting a.tyrosine protein kinase     b.tubulin protein polymerisation c.both of these                       d.any of the above	a
36	tumor is detect when its cell count is near by a.109         b.1011         c.107             d105	a
37	select the antimetabolite (anticancer) which is purine antagonist a.azathioprine    b.fludarabine    c.cyatarabine   d.both a and b	d
38	highly emetogenic anticancer drug is a.cisplatin    b.ifosfamide    c.busulfan     d.etoposide	a
39	chloramphenicol inhibit protein synthesis by by binding at ribosome a.30s     b.50s   c.30 and 50     d.either 30 or 50	b
40	alkylating agent generate highly active carbonium ion. which position of guanine is highly susceptible a.7   b.1          c.10        d.6	a