gpatadda: March 2017

1. p;

The receptors also named “Somatic receptors” are

a) M1 b) M2 c) NN d) NM

Natural vasodilator is

A.nitric oxide b) nitrous oxide c) adrenaline d) GABA

An Effective Antidote For Parathion Poisioning Is

a) pralidoximes b) naloxon c) fruseomide d) charcoal

The Gland Required To Be Targeted In Myasthenia Gravis Is

a) pineal b) thyroid c) thymus d) bone marrow

An Anti-Cholinergic Agent Used In Parkinsonism Is

a) trihexiphenidyl b) atropine c) pergyline d) homatropine

the drug not used in peptic ulcer is-

a) ranitidine b) omeperazole c) propanthiline d) dicylcomine

The Receptors Whose Agonist Can Result Hyperglycemia Are

a) α2 & β1 b) α1 & β2 c) α2 & β2 d) α1 & β1

The Drug Chiefly Causing “Tachyphylaxis Is

a) tyramine b) amphetamine c) isoprenaline d) ephedrine

The Drug Not Used By Sportsman For Anabolic Effect Is

a) amphetamine b) nandrolol c) stenazalol d) labetolol

10.

Ergot alkaloids are

alpha, 5-HT partial agonist, beta blockers

alpha, 5-HT blockers, beta agonist

alpha, beta agonist, 5-HT blockers

alpha, 5-HT, beta agonists

11.

The Receptor Whose Agonists Are Used By Sportsman For Anabolic Effect Is

a) α1 b) α2 c) β1 d) β2

12.

The choline ester resistant to both true and pseudocholinesterase is:

a. methacholine b. bethanechol c. benzoylcholine d. butyrylcholine

13.

Select Antagonist At M1 Receptor

a.oxotremorine b.mcn-343a c.pirenzepine d.all of these

14.

The Following Inhibitor Binds Only To The Ani-Onic Site Of The Cholinesterase Enzyme:

a. neostigmine b. physostigmine c. edrophonium d. dyflos

15.

Organophosphate Bind To Which Site Of Cholinestrase

a.anionic site b.esteric site c.both of these d.none

16.

Select The Lipid Insoluble Anticholinestrase

a.physostigmine b.neostigmine c.organophosphate d.donepezil

17.

currently, the first choice drug for open angle glaucoma is:

a. miotic eye drops b. ocular alpha 2 adrenergic agonists

c. ocular prostaglandin analogues d. ocular beta adrenergic blockers

18.

Myasthenia Gravis Is A Auto Immune Disease

i.it occur due to development of antibody against nicotinic receptors(nm)

ii.treatment is usually started with neotigmine but half life is short

iii.pyridostigmine is an alternative which needs less frequent dosing due to long half life

iv.this disorder affect 1000 in 10000 people

correct statement

a.i,ii,iv b.i,ii,iii c.ii,iii,iv d.i,ii,iii,iv

19.

edrophonium is more suitable for differentiating myasthenic crisis from cholinergic crisis because of its:

a. shorter duration of action b. longer duration of action

c. direct action on muscle end-plate

d. selective inhibition of true cholinesterase

20.

In Belladonna Poisioning Which Specific Antidote Is Used

a.atropine sulphate i.v b.physostigmine i.v

c.both of these d.no specific antidote available

21.

Which Statement Is Correct About Organophosphate

a.they are lipophilic b.they are easily absorbed through skin

c.reversible cholinesterase d.all of these

22.

Which Anti Cholinesterase Drug Is Not Used For Alzheimer Disease

a.neostigmine b.tacrine c.rivastigmine d.donepezil

23.

which of the following anticholinestrase was ist time used in alzheimer disease

a.rivastigmine b.tacrine c.physostigmine d.neostigmine

24.

Select The Synthetic Anticholinergic

a.homatropine b.ipratropium bromide c.cyclopentolate

d.all of these

25.

Which of the following mydriatics has the fastest and briefest action:

a. atropine b. homatropine c. tropicamide d. cyclopentolate

26.

the following mydriatic does not produce cycloplegia:

a. phenylephrine b. tropicamide c. cyclopentolate d. homatropine

27.

Which of the following is a noncatecholamine sympathomimetic:

a. adrenaline b. ephedrine c. dopamine d. isoprenaline

28.

Choose the correct statement about nicotine:

a. it selectively stimulates parasympathetic ganglia

b. it has no clinical application

c. it is used as an aid during smoking cessation

d. it is used in alzheimer's disease

29.

The following is a selective alpha-2 adrenoceptor antagonist:

a. prazosin b. phentolamine c. yohimbine d. clonidine

30.

the following sympathomimetic amine has agonistic action on a1 + a2 + b1 + b3 adrenoceptors, but not on b2 receptors:

a. adrenaline b. noradrenaline c. isoprenaline d. phenylephrine

31.

Sildenafil is contraindicated in patients taking the following class of drugs:

a. a-adrenergic blockers b. b-adrenergic blockers

c. organic nitrates d. angiotensin converting enzyme inhibitors

32.

What Is True Of Sildenafil:

a. it enhances sexual enjoyment in normal men

b. it delays ejaculation

c. it improves penile tumescence in men with erectile dysfunction

d. it blocks cavernosal a2 adrenoceptors

33.

Propranolol does not block the following action of adrenaline:

a. bronchodilatation b. lipolysis c. muscle tremor d. mydriasis

34.

The following disease is worsened by propranolol:

a. glaucoma b. raynaud’s disease c. benign prostatic hypertrophy

d. parkinsonism

35.

Select The Non Selective Beta Blocking Drug

a.propranolol

b.betaxolol

c.esmolol

d.all of these

36.

Which Beta Blocker Drug Is Highly Lipid Soluble

a.propranolol

b. labetalol

c.acebutolol

d.sotalol

37.

Propranolol

Proranolol is equipotent local anesthetic as lidocaine

Chronic use of propranolol decreases hepatic blood flow, so metabolism decreases and t_1/2 increases

Use of propranolol cause increase in LDL, Triglyceride level

It decrease intraocular tension without affecting pupil size

all

38.

Beta 1 Blocker Decrease Rennin Release Except

a.pindolol b.propranolol c.sotalol d. all

39.

Which of the following is partial agonist

Pindolol b.acebutolol c. Both d. none

40.

Which of the following beta blocker have low lipid solubility

a.atenolol b.sotalol c.bosoprolol d.all

41.

Impurities in pharmaceutical preparation may be due to following sources:

(a) Raw material (b) Manufacturing process

42.

Sterile water for injection may be stored in

(a) Type 1 (b) Type 2 (c) Both (a) and (b) (d) Type 3

43.

Hydrogen peroxide is used as

(a) antiseptic (b) acidifying agent (c) protective (d) antioxidant

44.

Halogenation mechanism occurring with antiseptic are

(a) hypohalite (b) sulphydryl

45.

Example of strong acid is

(a)	Ca²⁺	(b) Hg⁺
(c)	I⁺	(d) Cu⁺

46.

Side effect of Ca containing antacid.

(a) Renal failure (b) Mille allkali syndromes

47.

Expectorant are used in treatment of respiratory tract by

(a) ↑ viscosity of bronchial sec (b) ↓ viscosity of bronchial sec

(d) both (b) and (c)

48.

The antioxidants action of sodium metabisulphite is due to

(a) release of sodium ions (b) release of SO₂

49.

1 rad is equivalent to

(a) 10^–3 JKg^–1 (b) 10^–5 JKg^–1

50.

Gold-198 used in the treatment of

(a) pernicious anaemia (b) rheumatoid arthritis (c) detection of tumours (d) thyroid functioning

51.

I-125 is used as

(a) thyroid functioning

(b) to detect and estimate drugs hormones in the body fluid

52.

Chromium 51 is supplied as sodium chromate solution or injection it is used for

(a) to label rbc

(b) diagnosis of various infections (c) cisternography

(d) ventriculography

53.

1 Becqurel is equivalent to

(a) 2.7 × 10^–11 curie (b) 2.7 × 10^–10 curie (c) 2.7 × 10^–8 curie (d) 2.7 × 10^–5 curie

54.

ZnSO₄ is official as a topical astringent

a) True b) false c) none

55.

Ferritin is water insoluble crystelline iron protein

a) True b) false c) none

56.

Sodium nitrite is classified as

(a) chemical antidote (b) physiological antidote (c) mechanical antidote (d) all the above

57.

In Wilson disease a condition of excess storage of

(a) Fe (b) Zn

58.

CuSO₄ is essential component of

(a) Fehling solution (b) Benedict solution (c) Tolland reagent (d) Both (a) and (b)

59.

Beta particles penetrate tissue up to

(a) 100 cm (b) 1000 cm

60.

Which of the following is not a type of gas filled detector?

(a) Proportional counter (b) G.M counter

61.

Anaemia can be caused by

(a) excessive blood loss. (b) excessive blood formation. (c) both (a) and (b) (d) none of the above

62.

Cu deficiency can lead to

(a) Leucopenia (b) Ganulocytopenia (c) Anemia (d) All of the above

63.

Iodine is essential constituent of

………………… hormone

a).insulin b) thyroid c) testosterone d) adrenaline

64.

Iodine has been used therapeutically as

(a) ameliorating agent in hyper-thyroidism

(b) fibrocystic agent in syphilis (c) expectorant

(d) all of the above

65.

Ferrous gluconate has more bioavailability then ferrous fumerate

a) True b) false c) none

66.

The use of sodium rose Bengal (I-131) in

(a) study of K ion exchange (b) liver scan

67.

Ferritin and Hemosiderin are iron storage protein found in liver, spleen and bone marrow

a) True b) false c) none

68.

Potassium therapy is contraindicated in patient

(a) impaired renal fxn (b) acute dehychation (c) myotonia congenital (d) all of the above

69.

In metabolic acidosis

(a) HCO₃ excess (b) CO₂ decreased (c) HCO₃ deficit

(d) all of the above

70.

The category of calcium gluconate is (a) antacid

(b) calcium replenished (c) antioxidant (d) radiopharmaceuticals

71.

The category of sodium dihydrogen phosphate dehydrate is

(a) antacid

(b) calcium replenisher (c) urinary acidifier

(d) respiratory stimulant

72.

Calcium levulinate is used as calcium replenisher, chemically it is

(a) calcium-2-oxo pentanoate dehydrate

(b) calcium-3-oxo pentanoate dehydrate

(d) calcium-5-oxo pentanoate dehydrate

73.

AN example of expanded role of the pharmacist is

a) Community leader

b) Preparation of compounded prescription

c) Maintain adequate inventory of orphan drugs

d) Triages of pharmacist

74.

A pharmacist is presented a prescription for 250 mcg of levothyroxine.Which of the following dosages would be equivalent to that amount?

a) 2.5 mg

b) 0.25 gm

c) 0.25 mg

d) 25 gm

75.

Parental calcium is used as antidote for which of the following condition?

a) verapamil overdoses

b) hyperkalemia

c) cocaine intoxication

d) verapamil overdoses and hyperkalemia

76.

Which of the following emission from the decay of radionuclide is most commonly used in nuclear medicine diagnostic imagining?

a) x- ray

b) β

c) α

d) Gamma

e) Positron

77.

a) Which of the following radionuclide is most commonly used in nuclear pharmacy practice?

b) gallium-67 ( 6 7Ga)

c) thallium-201 (2 0 1Tl )

d) technetium-99m ( 9 9mTc)

e) iodine-123 (1 2 3 I )

f) xenon-133 ( 1 3 3Xe)

78.

R_xis Latin term whose meaning

a) Subscription

b) Inscription

c) Superscription

d) None of these

79.

Subscription is related to

a) Requesting GOD for quick recovery of the patient

b) Direction to pharmacist for preparing prescription and no.of doses to be dispensed

c) Direction given to the patient regarding the dose administration

d) Give information regarding habit forming drugs

80.

Dolore urgente is Latin term whose meaning

a) Before meals

b) Frequently

c) When the pain is severe

d) None of these

81.

Mitte is Latin term whose meaning

a) To be applied

b) Send

c) As a dose

d) In the manner prescribe

82.

Minimum space required to run a drug store

a) 150 sq.ft

b) 250 sq.ft

c) 300 sq.ft

d) 350 sq.ft

83.

No. of pharmacist required in a hospital of bed strength up to 300

a) 5

b) 8

c) 10

d) 15

84.

Thymol, Menthol and camphor leads to incompatibility which is known as

a) Physical

b) Chemical

c) Therapeutic

d) None of theses

85.

Error in dosage leads to incompatibility which is known as

a) Physical

b) Chemical

c) Therapeutic

d) None of these

86.

What quantities of 95 % v/v and 45 % v/v alcohols are to be mixed to make 800 mL of 65 % v/v alcohol?

a) 480 mL of 95 % and 320 mL of 45 % alcohol

b) 320 mL of 95 % and 480 mL of 45 % alcohol

c) 440 mL of 95 % and 360 mL of 45 % alcohol

d) 360 mL of 95 % and 440 mL of 45 % alcohol

87.

Drugs in suspensions and semi-solid formulations always degrade by

a) first order kinetics

b) second order kinetics

c) zero order kinetics

d) non-linear kinetics

88.

Term sparingly soluble (Approximate quantities(ml) of solvent by volume for 1 part (1 gm) of solute by weight) means according to I.P

a) From 1 to 10 parts

b) From 10 to 30 parts

c) From 30 to 100 parts

d) From 100 to 1000 parts

89.

Taste sensation Sour is recommended for which flavor

a) Vanilla

b) Wintergreen mint

c) Liquorice

d) Walnut

90.

Simple syrup NF contains 85% w/v sucrose

a) 85% w/v

b) 85% w/w

c) 66.67 % w/w

d) 66.67 % v/v

91.

The patient receives the usual dose of the certain medication one teaspoonful contain administered volume

a) 3 ml b)5 ml c)10 ml d)15 ml

92.

Draves test is associated with measuring the efficacy of

Wetting agent

Suspending agents

Detergents

Adsorbents

93.

Which type of cream is superior

a) o/w type

b) w/o type

c) Both

d) No difference exist between them

94.

A Sweeper in COP (Rohtak) is currently using En-De-Kay daily fluoride mouth rinse under the recommendation of his dentist. The mouth rinse contains sodium fluoride at a concentration of 0.05%. What weight of sodium fluoride is contained in each 10 mL volume with which he rinses his mouth?

a) 5000 micrograms

b) 50 micrograms

c) 5 micrograms

d) 0.5 microgram

95.

A patient weighs 14 kg and requires drug A at a dose of 5 mg/kg per day. What is the total daily dose for this patient?

a) 70 000 micrograms

b) 70 000 mg

c) 0.007 g

d) 70 g

e) 0.007 kg Droplets are red, background is colorless

96.

Ratio of oil:water:gum, if fixed oil is using in making emulsion

a) 2 : 2 : 1

b) 3 : 2 : 1

c) 4 : 2 : 1

d) None of above

97.

Largest size of capsule shell is

a) 000

b) 00

c) 1

d) 4

e) 5

98.

Cocoa butter exhibit polymorphism having no. of polymorph

a) 1 b)2 c)3 d)4

99.

Mandl’s paint is also known as

a) Crystal Violet Paint

b) Compound Iodine Paint

c) Tannic acid Glycerin Paint

d) Phenol glycerin Paint

100.

Aspartame approximately 200 times sweeter than sugar is methyl ester of

a) Aspartic acid and phenylalanine

b) Glutamic acid and phenylalanine

c) Glycine and phenylalanine

d) None of these

101.

Sweetened hydroalcoholic solution is known as

a) Syrup b)Aromatic water c)Elixirs d) Spirit

102.

The all followings are growth harmone except

a) Absicic acid b) dormin c) ethylene d) IAA

103.

Which of following is a gaseous harmone

a) IBA b) NAA c) Abscic acid d) Ethylene

104.

Which of following is widely used as rooting harmone

a) 2,4 D b) NAA c) 2,4,5-T d)cytokinin

105.

Is Known as father of medicine?

a)Aristotle b) Dioscorides

c)Hippocratesd) Galen

106.

Drug is not under the class of organized drug :

a) Leaves b) flowers

c) Fruits d) Gums

107.

Which is true for DDT ? it is

a) not a pollutant b) an antibiotic c)an antiseptic agent d) a non degradable pollutant

108.

Insecticide generally attack

a) respiratory system

b) nervous system

c) muscular system

d)circulatory

109.

Fabaceae is alternative name of

a) rutaceae b)Umbelliferae c) Leguminosae d) Liliaceae

110.

Polyploidy

a) is the process of genome doubling that gives rise to organisms with multiple sets of chromosomes

b) is the process of genetic material doubling that gives rise to organisms with multiple sets of chromosomes

c) is the process of mutation

d) none of above

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