1.
|
Time: 1 hour GPAT ADDA ACADEMY
Test Series.-1 I CAN AND I WILL……… TOTAL QUESTION-100
Add.- Vinayak complex,
D-park, rohtak, contact no. 8901408422,
9671935154
Which
of the sulphonamide is a prodrug
A.sulfadiazine b.sulfadoxine c.sulfasalazine d. All of these
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C
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2.
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Which
sulphonamide is short acting
A.sulfadoxine b.sulfamethopyrazine c.sulfamethoxazole d.sulfadiazine
|
D
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3.
|
Which
of the sulphonamide is topically used
A.mafenide b.sulfacetamide sodium c.both of these d.sulfadiazine
|
C
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4.
|
Sulfamethoxazole
was selected for combining with trimethoprim because
A.both
have same half life b.both
adequately cross blood brain barrier
C.both
a and b d. None of
these
|
A
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5.
|
Fluoro
quinolones are
A.
natural b. Semisynthetic c. Synthetic d.natural+semisynthetic
|
C
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6.
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Methyl
derivative of norfloxacin is
A.ofloxacin b.pefloxacin c.ciprofloxacin d.sparfloxacin
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B
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7.
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Most
potent fluoro quinolones is
A.
Ofloxacin b.pefloxacin c.ciprofloxacin d.norfloxacin
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C
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8.
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Name
the penicillin resistant to both penicillinase and acid
A.penicillin
– v b.methicillin c.ampicillin d.cloxacillin
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D
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9.
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Extended
spectrum penicillin
A.penicillin
– v b.methicillin c.ampicillin d.cloxacillin
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C
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10.
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Beta
lactamase inhibitors
A.sulbactam b.mezlocillin c.carbenicillin d.both a and c
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A
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11.
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Sulphonamide
side effect
A.jarisch
herxheimer reaction b.stevens
johnoson syndrome
C.both
of these
d.hallucinations
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B
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12.
|
Diabetes
insipidus is caused by which tetracycline
A.oxytetracyclin b.doxycycline c.minocycline d.demeclocycline
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D
|
13.
|
Diarrhoea
is side effect of tetracycline,,,decrease in incidence of diarrhoea by using
which tetracycline
A.tetracycline b.doxycycline c.oxytetracycline d.demeclocycline
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B
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14.
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Which
tetracycline is semisynthetic
A.doxycycline b.minocycline c.both of these d.none of these
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C
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15.
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Which
preparation of tetracycline banned
A.dry
syrups b.liquid oral
preparations c.both of these d.none of these
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C
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16.
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Tetracycline
are not recommended by which route
A.i.m. B.intrathecally c.oral
d.both a and b
|
D
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17.
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Tetracyclins
have chelating property with
A.calcium b.milk
c. Both of these d.none of
these
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C
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18.
|
Chloramphenicol
is obtained from
A.streptomyces
chrysogenum b.streptomyces
notatum
C.sterptomyces venezuelae d.all of these
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C
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19.
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Adverse
effect of chloramphenicol
A.grey
baby syndrome b.fancony syndrome c.both of these d.tin tin syndrome
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A
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20.
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Which
prodrug of chloramphenicol is soluble
A.
Chloramphenicol palmitate b. Chloramphenicol
succinate
C.both
of these d.none
of these
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B
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21.
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Red
man syndrome is caused by
A.erythromycin b.vancomycin c.clindamycin d.all of these
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B
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22.
|
Vancomycin
act by inhibiting
A.cell
wall synthesis b.protein synthesis c.both of these d.DNA gyrase
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A
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23.
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Which
of the following is a prodrug
A.sulfasalazine b.isoniazid c.both a and b d.none of these
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C
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24.
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Chloramphenicol
inhibit protein synthesis by by binding at ribosome
A.30s b.50s
c.30 and 50 d.either 30 or
50
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B
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25.
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Sulphonamide
is sterilised by
A.hot
air ovan b. Moist heat
sterilisation c. Tyndallisation d. Gamma rays
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A
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26.
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Which
of the following is used for the extraction of antibiotic
A.abc
extractor b. Rotary extractor c.
Podbielnaik extractor
D.
Whitle extractor
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C
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27.
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Which
of the following is the precursor of penicillin
A.l-tryptophan b. Phenyl acetic acid c. Tyrosine d.
L- dopa
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B
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28.
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Which
of the following technique is used for purification of streptomycin
A.ion
exchange b. Reverse osmosis c. Both
a and b d. None
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A
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29.
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Name
the acidic drug
A.novobiocin b. Erythromycin c. Streptomycin d. None
of the above
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C
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30.
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Murein
content in
A.70-80%
in gram +ve b. 70-80% in gram
-ve
C.
10-20% in gram +ve d. None of these
|
A
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31.
|
Teichoic
acid is present in
A.gram
+ve b. Gram –ve c. Brucellosis d. All of these
|
A
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32.
|
Endotoxin
is produced by
A.lysozyme b. Gram +ve c. Gram –ve d. All of these
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C
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33.
|
Toxicity
of endotoxin is due to
A.lipid
a b. Lipid b
c. Lipid o d. None of these
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A
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34.
|
Structural
component which is unique to gram –ve
(of outer membrane) is
A.polysaccharide b. Lipopolysaccharide c.glycopolysaccharide
D.mycolic
acid
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B
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35.
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Which
of the following is gram –ve bacteria
A.bacillus
anthracis
b.clostridium tetani
C.staphylococcus
aureus d.salmonella
typhi
|
D
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36.
|
Which
of the following is gram +ve bacteria
A.vibrio
cholera
b.e. Coli
C.cornybacterium
diphtheria d. Neisseria gonorrhoeae
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C
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37.
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Dust
borne infection is
A.diphtheria b. Typhoid c. Both of these d.none of these
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D
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38.
|
Which
beta lactam antibiotic shows least hypersensitivity reaction
a.
Penicillin b. Aztreonam c. Cephalosporin d. Carbapenem
b.
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B
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39.
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Which
of the carbapenem degraded by dehydropeptidase
a.
Meropenem b. Imipenem c. Doripenem d. All of these
b.
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B
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40.
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Which
of the following have no antibiotic effect
a.
Monobactam b. Clavulanic acid c. Both a and b d. None
b.
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B
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41.
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Select
the very low therapeutic index drug
a.
Beta lactam antibiotic b. Vancomycin c. Both a and b d. None
b.
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B
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42.
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Select
the true for tetracycline
a.
Highly phototoxic tetracycline 1.doxycycline
b.
Semisynthetic tetracycline 2.demeclocycline
c.
Safer tetracycline in liver damage 3.minocycline
d.
Highly potent tetracycline 4.oxytetracycline
a. A-1,
2-b,3-c, 4-d b. A-2, b-1,
c-4, d-3
C.a-1,b-2, c-3, d-4 d. A-1, b-2, c-4, d-3
|
B
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43.
|
Which
is not Degraded product of tetracycline
a.
Epitertacycline b. Chlotertacycline c.anhydrotetracycline
e.
Epianhydrotetracycline
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B
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44.
|
Cilastatin
drug used with
a.
Imipenem b. Doripenem c.meropenem d. All
b.
|
A
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45.
|
Fifth generation cephalosporin used by
a.
Orally b.parentrally c. Both d.none
b.
|
B
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46.
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Which
drug is ist generation cephalosporin
a.
Cefaclor b. Cefuroxime c. Cefepime d. Cefadroxil
b.
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D
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47.
|
Which
of the following is prodrug
a.
Amoxicillin b.benzathine penicillin c. Talaampicilline d. None
b.
|
C
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48.
|
Select
bacteriocidal drug
a. Sulphonamide b. Tetracycline c. Aztreonam d.all
|
C
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49.
|
Fluoroquinolone
drug which prolong QT interval
(cardiac arrythmia)
a.
Gatifloxacin b. Ciprofloxacin c. Ofloxacin d. All
b.
|
A
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50.
|
Longest
acting fluoroquinolone
a.
Ciprofloxacin b. Ofloxacin c.sparfloxacin d.all
b.
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C
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51.
|
Cross
resistance example
a.
Sulphamethoxazole and
sulfadiazine
b.
Oxytertacycline and demeclocycline
c.
Erythromycin and clindamycin
d.
Tetracycline and chloramphenicol
e.
All of these
f.
Both c and d
g.
|
E
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52.
|
Concentration
dependent antibiotic effect
a. Gentamicin b. Quinolones c. Aminoglycoside d. All
e. Both a and b
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D
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53.
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Time dependent antibiotic effect
a. Gentamicin b. Quinolones c. Beta lactam d. All
|
C
|
54.
|
international
pharmacopoeia is published by
A AICTE B UGC C GMP D WHO
|
D
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55.
|
what
is proportion of oil, water, and gum acacia for fixed oil
A 4:2:1 B 2:2:1 C 3:2:1 D 2:4:1
|
A
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56.
|
The
new edition of IP is published after every
A
4 year B 5 year C 6 year D 3 year
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D
|
57.
|
At
what temp the blood is strored
A
15◦c B
4◦c
C 0◦c D 10◦c
|
C
|
58.
|
the
first edition of Indian pharmacopoeia is published in the year
A
1940 B 1985 C 1955 D 1950
|
C
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59.
|
which is known as BAL (British
anti-lewisite)
A
diamecaprol B carbon dioxide C magnesium oxide D calcium oxide
|
A
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60.
|
Drugs in suspensions and semi-solid
formulations always degrade by
a first
order kinetics
b second order kinetics
c zero
order kinetics
d non-linear kinetics
|
C
|
61.
|
Ratio of oil: water: gum, if oleo-resins is
using in making emulsion
a 2
: 2 : 1
b 3 : 2 : 1 c 4 : 2 :
1
d None of above
|
A
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62.
|
Ratio
of oil: water: gum, if code liver oil is using in making emulsion
a 2
: 2 : 1
b 3 : 2 : 1 c 4 : 2 :
1 d None
of above
|
C
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63.
|
the
5th edition of Indian pharmacopoeia is published in the year
A
2002 B 2010 C 2007 D 2012
|
C
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64.
|
According
to IP 1996 temperature range of injection streptomycin sulphate
A -4 ◦c B -2
◦c C -8◦c D -15◦c
|
A
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65.
|
According
to (USP 1995) temperature rang cool places?
A 8-25◦c B 2-8 ◦c C 8-15 ◦c D 10-15◦c
|
C
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66.
|
According
to IP 1996 temperature range of heparin injection
A -10◦c B -15
◦c C -20
◦c
D -8 ◦c
|
B
|
67.
|
What
is blood ph
A 7.2 B 7.4
C 7.5 D 7.1
|
C
|
68.
|
Most
of drugs follow which order?
A first order B zero order C
pseudo order
D mixed order
|
A
|
69.
|
Suspensions
OR semisolid dosage forms which order follow?
A
first order B zero order C
pseudo order
D mixed order
|
B
|
70.
|
When
a drug absorption in body how many half life required? c
A
4 B 7
C 5 D 3
|
C
|
71.
|
The
dye used to give desired color to
cosmetics should be approved by
A
FDA B FD & C C both a & b D WHO
|
B
|
72.
|
What
is range of ph of vehicle in formulating nasal drops?
A
5.5- 7.5 B 5.1-7.1 C 5.1-7.8 D 5.1-7.8
|
A
|
73.
|
Fennel contains type of stomata:
a Diacytic b
Actinocytic c
Anisocytic d Anomocytic
|
D
|
74.
|
Cinnamom bark does not contain:
a) Cinnamaldehyde b)
Tannins c) Coumarin d)
Benzaldehyde
|
C
|
75.
|
The chemical name of guanine is
(A)
2,4-Dioxy-5-methylpyrimidine
(B) 2-Amino-6-oxypurine
(C)
2-Oxy-4-aminopyrimidine
(D) 2, 4-Dioxypyrimidine
|
B
|
76.
|
The sugar moiety present in DNA is
(A)
Deoxyribose (B) Ribose (C) Lyxose (D) Ribulose
|
A
|
77.
|
Which is not used as an adulterant for clove?
a) Mother
clove b) Blown clove c)
Clove stalk d) Pale clove
|
D
|
78.
|
Match the following tests with their
respective applications A to E:
1.
Schick test A.
Tuberculosis
2.
Mantoux test B. Detection
of extraneous microorganisms
3.
Sterility test C.
Diphtheria toxin
4.
Potency test D.
Usefulness of immunological products
Select
a.1-c,2-a,3-b,4-d b.1-a,2-c,3-b,4-d
c.1-c,2-a,3-d,4-b d.1-a,2-c,3-d,4-b
|
a
|
79.
|
In autoclave, the principle involved is
a.
Dry heat b. Moist heat c. Steam under pressur d. Both b and c
|
d
|
80.
|
The penicillin produced in large scale submerged
fermentations are
a.
Penicillin-A b. Penicillin-D c. Penicillin-G d. None of these
|
C
|
81.
|
The strain of fungi used for the large scale
production of penicillin is
a.
Penicillium chrysogenum b.
P-notatum
c.
Streptomyces Aurecus d.
Saccharomyces sps
|
A
|
82.
|
Vitamin B12 can be estimated and determined by
using organism
a.
Lactobacillus sps b.
Lactobacillus Leichmanni
c.
Bacillus subtilis d.
E.Coli
|
B
|
83.
|
Example for live vaccine is
a.
Rubella & BCG b.
Polio & TAB
c.
Diphtheria & Tetanus d.
Hepatitis A & Rabies
|
A
|
84.
|
Vaccines are prepared from killed
microbes, they are
a.
Inactivated (killed) vaccine b.
Attenuated vaccines
c. Autogenous vaccine d. None of these
|
A
|
85.
|
Immunoglobulin is associated with anaphylactic
delayed hypersensitivity reaction
a.
IgE b. IgA c. IgD d. IgM e. IgG
|
A
|
86.
|
Killed, polio vaccine is
a.
Sabin vaccine b. Salk c. BCG d. TAB
|
A
|
87.
|
Antigen-antibody reactions are
a.
Reversible b. Irreversible c. Specific d. Both a and b
|
D
|
88.
|
The protein moiety of an enzyme is
known as
a.
Holo enzyme b. Apo enzyme c. Co enzyme d. Enzyme
|
B
|
89.
|
Bacteria which need oxygen for growth
are called
a.
Thermophilic bacteria
b. Microaerophilic bacteria
c.
Facultative anaerobic bacteria d.
Mycobacteria
|
B
|
90.
|
The enzymes which are commonly used in genetic
engineering are
a.
Exonuclease and ligase
b.
Restriction endonuclease and polymerase
c.
Ligase and polymerase
d.
Restriction endonuclease and ligase
|
A
|
91.
|
DNA transfer from one bacterium to another through
phages is termed as
a.
Transduction b. Induction c. Transfection d. Infection
|
A
|
92.
|
Lyophilization
is also known as :
(a) Drying by
sublimation (b)
Freeze drying
(c)Both a and
b
(d) none
|
C
|
93.
|
Triple
roller mill is used in mixing of:
(a) semi
solids (b) solids (c) liquids (d) none of these
|
A
|
94.
|
Endotoxin
are:
(a) Class of
pyrogen (b)
Lipopolysaccrides in nature
(c) Componets
of cell wall of gram negative bacteria (d)all
|
D
|
95.
|
Water
for injection :
(a)does
need to be sterile
(b)
Conductivity should not >1 micromho
(C)
purified by distillation or two stage reverse osmosis
(d)
all of above
|
D
|
96.
|
In dry milling moisture
should not be less than:
(a) 2
|
A
|
97.
|
Adulterants for clove Characteristics
a) Mother
clove i) Expanded flowers of clove trees.
b) Blown
cloves ii) Contain only 5% of oil.
c) Clove stalks iii) Oil
is removed from clove.
d) Exhausted
clove iv) iv) Dark brown, ovate and ripened
Fruits
of clove
A) a) iv b) i. c) ii d) iii C) a) iv b) ii. c) iii d) i
B) a) iv b) i. c) iii d) ii D) a) i b) iv. c) ii d) iii
|
A
|
98.
|
The family of Ocimum sanctum:
a) Labiatae b) Liliaceae c)
Lauraceae d) Loganaceae
|
A
|
99.
|
Which of the following is a non-reducing sugar?
(A)
Isomaltose (B) Maltose (C)
Lactose (D) Trehalose
|
D
|
100.
|
The sugar found in milk is
(A)
Galactose (B)
Glucose (C) Fructose (D) Lactose
|
D
|
Monday 30 October 2017
GPAT- 2018 TEST NUMBER- 1
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