Target GPAT-2018 General Pharmacology Series- 4

1. which of the following is a type b (unpredictable) adverse drug reaction: a. side effect b. toxic effect c. idiosyncrasy d. physical dependence	C
2. drugs producing allergic reactions generally act as: a. complete antigens b. haptenes c. antibodies d. mediators	B
3. which of the following is the only life saving measure in case of anaphylactic shock: a. intravenous hydrocortisone hemisuccinate b. intravenous chlorpheniramine maleate c. intramuscular adrenaline hydrochloride d. intravenous glucose-saline	C
4. intradermal drug sensitivity tests can detect the presence of following type of hypersensitivity: a. type i (anaphylactic) b. type ii (cytolytic) c. type iii (retarded) d. all of the above	a
the most vulnerable period of pregnancy for the causation of foetal malformations due to drugs is: a. 18-55 days of gestation b. 56-84 days of gestation c. second trimester d. 36 weeks onwards	A
functional proteins that are target of drug action i.enzymes ii.transporters iii.ion channels iv.receptors correct a.i,ii,iii b.ii,iv c.i,ii d.i,ii,iii,iv	D
5. which of the following drug is a competitive inhibitor of enzyme but non equilibrium type a.physostigmine compete with acetycholine for cholinesterase b.sulfonamide compete with paba for bacterial folate synthase c.allopurinol compete with hypoxanthenes for xanthine oxidase d.organophosphate compete with acetylcholine for cholinestrase	D
6. which of the following drug is not a non competitive inhibitor of enzyme a.acetazolamide inhibit carbonic anhydrase b.disulfiram inhibit aldehyde dehydrogenase c.digoxin inhibit na k atpase d captopril inhibit ace enzyme	D
7. select the drug act through  ion channel a.ethosuximide b.amiloride c.both a nd b d.none of these	C
select the drug act through transporters i.fluoxetine ii.phenytoin iii.furosemide iv.desipramine correct a.i,ii,iii b.i,iii,iv c.ii,iii,iv d.i,ii,iii,iv	b
select the wrong statement a.competitive antagonist have high affinity  and high intrinsic activity b.partial agonist have affinity and sub maximal intrinsic activity c.inverse agonist have affinity but intrinsic activity with a minus sign d.agonist have both high affinity and maximal intrinsic activity	A
8. select the partial agonist a.naloxone b.pentazocine c.atropine d.morphine	B
9. select the competitive antagonist a.propranolol b.atropine c.naloxone d.all of these	D
10. select the following which act through enzyme linked receptors a.insulin b.epidermal growth factor c.both of these d.gaba-a	C
11. which of the following is ion channel receptor i.gaba,glycine ii.nmda,5-ht3 iii.nicotinic cholinergic iv.5-ht1,dopamine correct a.i,ii,iii,iv b.i,ii,iii c.ii,iii,iv d.i,ii,iv	b
12. which of the following is a g protein coupled receptor, act through ip3 dag pathway a.muscarinic-1 b.muscarinic-2 c.muscarinic-3 d.all a,b,c e. both a and c	e
13. histamine is a g coupled protein receptor,which of the following statement is true a.h-2 act through adenylyl cyclase pathway by increasing camp b.h-1 act through ip3 dag pathway c. h-2 act through adenylyl cyclase pathway by decreasing camp d.both a  and b	d
14. select the ligand act through ip3 dag pathway(gpcr) a.5-ht2 b.5-ht1 c.5-ht3 d.all of these	a
15. vit-a and d act through a.gpcr b.ion channel c.nuclear receptor d.enzyme linked receptor	c
16. select the intracellular receptor  a.gpcr b.ion channel c.nuclear receptor d.enzyme linked receptor	c
17. A receptor which itself has enzymatic property is: a. insulin receptor b. progesterone receptor c. thyroxine receptor d. glucagon receptor	a
18. ‘drug efficacy’ refers to: a. the range of diseases in which the drug is beneficial b. the maximal intensity of response that can be produced by the drug c. the dose of the drug needed to produce half maximal effect d. the dose of the drug needed to produce therapeutic effect	b
19. which of the following is always true: a. a more potent drug is more efficacious b. a more potent drug is safer c. a more potent drug is clinically superior d. a more potent drug can produce the same response at lower doses	d