Target GPAT-2018- General Pharmacology Series-2

21	which of the following statements is correct? a. if 10 mg of drug a produces the same response as 100 mg of drug b, drug a is more efficacious than drug b. b. the greater the efficacy, the greater the potency of a drug. c. in selecting a drug, potency is usually more important than efficacy. d. a competitive antagonist increases the ed50	d
22	hypnotics like diazepam or nitrazepam have short pharmacological action(6-8 hours) because a.because their elemination  t1/2 is 6-8 hours b.due to redistribution c.both of these d.none of these	c
23	in a healthy person (70 kg),total fluid volume is 42 litr(approx).which involve i..14 litre extracellular fluid ii.28 litre intracellular fluid iii. plasma=4 litr iv.interstitial fluid=10 litre select the correct group a.i,ii,iii,iv b.i,ii,iii c.i,ii,iv d.i,ii only	a
24	which of the pair is not highly vascular a.heart,lung b.liver,brain c.kidney,lung d.muscle,fatty tissue	d
25	drugs with high molecular weight and high plasma protein binding also hydrophilic in nature mainly restricted to a.extracellular compartment b.intracelluar compartment c.both of these d.none	a
26	which statement is correct a.streptomycin and gentamicin are hydrophilic so these drugs mainly restriced to extra fluid compartment b.digoxin,propranolol,morphine show large volume of distribution c.drugs which show large volume of distribution are not easily removed by haemodialysis in case of poisioning d.all of these	d
27	factors which affect volume of disribution a.disease like chf, uremia,cirrhosis b.fat c.pka d.plasma protein binding correct statement is a.i,iii,iv b.i,ii,iii,iv c.i,ii,iii d.ii,iii,iv	b
28	drug concentrated in adipose tissue i.thiopentone ii.ddt iii.digoxin iv.minocycline correct statement a.i,ii,iii b.i,ii,iv c.ii,iii,iv d.i,iii,iv	b
29	orally administered sabine polio  vaccine is absorbed by a.pinocytosis b.phagocytosis c.ion transport d.all of these	a
30	acidic drugs generally bound to a.albumin b.alpha 1 acid glycoprotein c.both of these d.tyrosine	a
31	select the drug which show important displacement interactions a.sulfonamide displace bilirubin b.vitmin k displace bilirubin c.salicylates displace sulfonylureas d.all of these	d
32	high degree of protein binding a.make drug long acting b.bound drug not available for metabolism c.highly protein binding drugs are not removed by haemodialysis in case of poisioning d.all of these	d
33	primary site of drug metabolism is a.liver b.kidney c.lungs d.intestine	a
34	select the group which is not a  prodrug (group) a.levodopa,dipivefrine b.sulindac,sulfasalazine c.proguanil,mercaptopurine d.losartan,imipramine	d
35	select the phase ii reaction a.reduction b.oxidation c.acetylation d.hydrolysis	c
36	microsomal enzymes present on/in a.smooth endoplasmic reticulum b.cytoplasm c.mitochondria d.plasma	a
37	select the microsomal enzymes a.monooxygenase b.cyt-p450 c.glucuronyl transferase d.all of these	d
38	non microsomal enzymes catalysed all reaction except a.oxidation b.reduction c.sulfate conjugation d.glucuronidation	d
39	drugs which metabolised by enzyme a.allopurinol by xanthine oxidase b.adrenaline by monoamine oxidase c.succinyl cholie by cholinestrase d.all of these	d
40	select the follwing which cause microsomal enzyme induction a.drugs like phenobarbiton,isoniazid,griseofulvin,rifampin b.carcinogens c.insecticides d.all of these	d