Time: 1 hour GPAT
ADDA ACADEMY Test
No.-2
I CAN AND I WILL………
(Vinayak complex,
D-park, rohtak, contact no. 8901408422, 9671935154)
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1.
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Increase
in the extent of conjugation of a bonded system result?
A
bathochromic shift B hyperchromic
shift C
hypochromic shift D
hypsochromic shift
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A
|
|
2.
|
Sodium
chloride material is used in which type of spectroscopy
A
X-ray diffraction B IR- Spectroscopy C UV Spectroscopy D colorimetry
|
B
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3.
|
Quarts
material is used in which instrumental technique as
A
X-ray diffraction B IR- Spectroscopy C UV
Spectroscopy D colorimetry
|
C
|
|
4.
|
Energy
absorbed in UV region produces changes in the
A
rotational energy of molecules B vibrational energy of molecules C electronic energy
of molecules D all of them
|
C
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|
5.
|
Hypsochromic
shift also known as
A
blue shift B red shift C green shift D none of these
|
A
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6.
|
Monochrometor
is not used in
A
Spectrofluorimeter B IR-
Spectroscopy C UV Spectroscopy D FTIR spectrometer
|
D
|
|
7.
|
The
chemical shift value is
A
ratio of the number of protons in the each group
B
proportional to the total number of protons
C
proportional to field strength
D
not proportional to field strength
|
C
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8.
|
Which
instrument used in golay pneumatic detector is ?
A
Flame photometer B gas chromatography
C IR- Spectroscopy D UV Spectroscopy
|
C
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|
9.
|
The
wavelength source in NMR spectrometer is ?
A
goniometer B
dropping mercury electrode
C klystron oscillator D radio frequency oscillator
|
D
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10.
|
Bathochromic
shift also known as
A
blue shift B red shift C green shift D none of these
|
B
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11.
|
IR
radiation can be expressed in
A
nonameter B wavelength C absorbance D transmittance
|
B
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12.
|
Which
term used in UV spectroscopy method is ?
A
antibonding orbital B
stretching and bending
C metastable ion D
chemical shift
|
A
|
|
13.
|
Green
colour given wavelength is
A
450-480 B 500-560 C 575-590 D 675-650
|
B
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14.
|
Conformation
of drugs commonly determine by
A
pH determination B mass
spectroscopy C NMR spectroscopy D NMI
|
C
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|
15.
|
Acetone
shows characteristics band in IR spectrum. Identify it
A
1500cm-1 B 1720cm-1 C 900cm-1 D 2600cm-1
|
B
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|
16.
|
The
region of the electromagnetic spectrum below 200 nm is known as?
A
far UV region B vacuum UV region C
low UV region D microwave region
|
B
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17.
|
The
method of expressing magnetic field strength is ?
A
debye units B pulse per
sec C gauss D cyclic/sec
|
D
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|
18.
|
Medium
IR region lies from?
A
3-15µ B 15-25µ C 2-8µ D 2.5-25µ
|
D
|
|
19.
|
Overtone
IR region lies from?
A
1.2-2.5µ B 2.5-25µ C 2-8µ
D
2.5-25µ
|
A
|
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20.
|
Chemical
shift is represent in
A
nm B mm C ppm D cm
|
C
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|
21.
|
IR
spectroscopy is convenient method for understanding of
A
drug-receptor interaction B functional group
identification
C
physiochemical properties D conformational
properties
|
B
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22.
|
Bolometer
consist of
A
two semi conducting metals welded together
B
a thin blackened pt strip in an evacuated vessel
C
tungsten wire D
none of the above
|
B
|
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23.
|
Reference
compound widely used in NMR spectroscopy for proton spectra in non-aqueous
medium
A
silane B tetramethyl silane TMS C
DPPH D peroxylamine disulphite
|
B
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24.
|
The
presence of one pair electron in metal ion comlex meantr for spectral
analysis is called
A
paramagnetic B
diamagnetic C bimagnetic D unimagnetic
|
B
|
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25.
|
Unit
of IR spectroscopy
A
cm B cm-1 C mm D µm
|
B
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26.
|
Beer’s law states that the intensity of
light decreases with respect to
a Concentration b Distance c Composition d Volume |
A
|
|
27.
|
Lambert’s law states that the intensity of
light decreases with respect to .
a. Concentration b Distance c Composition d
Volume
|
B
|
|
28.
|
Nujol
is
A
hexachlorobutadiene B mineral oil C perfluorokerosene D flurotube
|
B
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|
29.
|
Silicone
carbide rod heated to heigh temperature is used as a
A
detector in IR spectroscopy B source of light in IR
spectroscopy
C
source of light in UV spectroscopy D none of these
|
|
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30.
|
Tesla
is a unit used to expressed
A
frequency B gauss C pressure D magnetic field
|
D
|
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31.
|
Nuclear
magnetic moment is not shown by
A
13C B 16O C 1H
D 15N
|
B
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32.
|
Solvent
used in NMR studies is
A
chloroform B
acetone C carbon tetrachloride D methanol
|
C
|
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33.
|
Ratation
of electron about the proton generates a secondary magnetic field which may
oppose the applied magnetic field . the proton is then said to be
A
shielded B shifted C hydrogen bonded D deshielded
|
A
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34.
|
A
compound will be sensitive towards IR radiation only when one of the
following properties undergo transition
A
polarisability B dielectric constant
C dipole movement D refractivity
|
C
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35.
|
In
UV spectroscopy K bond occurs due to which of the following transition
A
π-π* B π-π C π- σ D σ- σ*
|
A
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36.
|
Which
solvent not used in IR spectroscopy
A
chloroform B H2O C CCl4 D CS2
|
B
|
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37.
|
α,
β-unsaturated carbonyl compounds are most conveniently identified by
A
UV spectroscopy B
colorimetry C IR D all the above
|
A
|
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38.
|
Is Known as father of medicine?
a)Aristotle b) Dioscorides c)Hippocrates
d) Galen
|
C
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39.
|
The
most commonly used in the UV
spectrophotometer is
A
photomultiplier tube B thermocouple C bolometer D littrow prism
|
A
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40.
|
The
region for IR range from
A
14290-4000cm-1 B 4000-666cm-1 C 700-200cm-1 D none of these
|
B
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41.
|
Bending
vibratioin including all of the following except
A
stretching B twisting C rocking D
torisional vibrations
|
A
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42.
|
Nernst
filament is fabricated from the oxide
A
zirconium B thorium C cerium D all of these
|
D
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43.
|
The
IR radiation source , Globar is chemically
A
silicon carbide B
silicon disulphite C zirconium D none of these
|
A
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44.
|
IR
spectra may be obtained for
A
solids B liquids
C gases D all of these
|
D
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45.
|
Pressed
disc technique for the sample preparation I IR involves the use of ‘
A
salt plates B nujol C KBr
D none of these
|
C
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46.
|
The
various kind of environmental effects that occur in NMR SPECTROSCOPY
A
chemical shift B spin-spin splitting C chemical exchange D both a & b
|
D
|
|
47.
|
The
range of C-H stretching alkene
A
3030-3010 B 3040-3020 C 3040-3010 D 2800-2810
|
C
|
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48.
|
The
range of O-H bending
A
1050-1400 B 1100-1300 C
1040-1350 D none of these
|
A
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49.
|
In
a paramagnetic chemical shift is
A
increase B
decrease C same D no effect
|
B
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50.
|
In
a paramagnetic chemical shift is
A
increase B decrease C same D no effect
|
A
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51.
|
Imipenem
is used with....... to block its breakdown in kidney
a)
Aztrenam
b) Cilastin c) Netilmicin d) Depsone
|
b
|
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52.
|
Acetyltransferase
is involved in the resistance of
a)
Tetracycline
b) Chloramphenicol c) Penicillin
d) Spectinomycin
|
b
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53.
|
Minocycline
is active when given as
a)
I.P b)
I.V c) Orally d)
Topically
|
c
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54.
|
CNS
side effect of Isoniazide
a)
Hallucination
b) Mania c)
Parkinsonism d) Seizures
|
d
|
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55.
|
Damage
of VIIIth nerve is a side effect of
a)
Pyrazinamide
b) Ethambutol c)
Cycloserine d) Cepreomycin
|
c
|
|
56.
|
Buffalo
humps is a side effect of
a)
Anti-viral
b) Anti-tuberculosis c) Anti-
fungal d) Anti-cancer
|
a
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57.
|
Which
term is fully correct
a)
Amantadine inhibits coating and is effective against influenza A virus
b)
Amantadine inhibits decoating and is effective against influenza virus
c)
Amantadine inhibits decoating and is effective against influenza A virus
d)
Amantadine inhibits coating and is effective against influenza virus
|
c
|
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58.
|
Mechanism
of azoles
a)
Lanosine 14α-demethylase
b)
Lanosine 14α-methylase
c)
Lanosine 14β-demethylase
d)
Lanosine 14β-methylase
|
a
|
|
59.
|
Chloroquine
is a
a.Anti-rheumatoid b.Anti-asthmatic c.Anti-biotic d.Anti-hypertensive
|
a
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60.
|
Quinine
can stimulates
a.Testosterones b.Estrogens c.Insulin d.None of these
|
c
|
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61.
|
Mechanism
of action of fluroquinolones
a)
DNA polymerase
c) RNA polymerase
b)
DNA gyrase d) RNA gyrase
|
C
|
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62.
|
More
promising chemotherapeutic agents for treating viral diseases is
a)
Leukocytic interferon c) Flbroblast interferon
b)
Interferon d) Nystatin
|
b
|
|
63.
|
The
larger the ...........................the better the chemotherapeutic agent
a)
Therapeutic index c) Therapeutic tolerance
b)
Spectrum d) Toxicity
|
a
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|
64.
|
Chelate forming peptide antibiotic are
a)
Bleomycins c) Vancomycin
b)
Sideromycins d) both a and c
|
d
|
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65.
|
Which
of the following protein synthesis mechanism may be affected by particular
drugs
a)
Peptide bond formation c)
Aminoacyl-tRNA binding
b)
mRNA translocation d) All of these
c)
|
d
|
|
66.
|
Vancomycine
inhibits peptidoglycan synthesis by binding
a)
D-alanyl-D-alanyl synthetase b.Alanin racemase
c.
D-alanyl-D-alanyl
d.Amidase
|
c
|
|
67.
|
Polymyxin
interfere with
a)
Cell member function b.Cell wall synthesis
c.
DNA function d.Protein synthesis
|
a
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|
68.
|
Shake
and bake is associated with
a)
Griseofulvin c) Amphotericin B
b)
Caspofungin d) Micofungin
|
c
|
|
69.
|
Glucans
targated antifungal is
a)
Allyamines
b) Polyenes c)
Echinocandin d) None of these
|
c
|
|
70.
|
Which
antifungal drug at high dose has an antiadrogen effect
a)
Ketoconazole c) Voriconazole
b)
Clotrimazole d) Fluconazole
c)
|
a
|
|
71.
|
Which
of the following statements correctly pair the antifungal drugs with their
likely mechanism of action?
a)
Amphotericin B - inhibits thymidylate synthetase
b)
Griseofulvin - interferes with microtubule
function
c)
Flucytosine - inhibits fungal mycolic acid
synthesis
d)
Miconazole - inhibits DNA dependent RNA polymerase
|
b
|
|
72.
|
Which
of the following statements regarding the toxicity of amphotericin B are
correct?
a)
Metabolic alkalosis is frequent and may be
pronounced
b)
A shock-like fall in blood pressure may occur
during IV infusion
c)
A sudden decrease of body temperature may occur
during IV infusion
d)
Renal toxicity is common, is dose-dependent and
may be severe
e)
Amphotericin B toxicity seems to be lower with the
use of lipid formulations the drug
|
|
|
73.
|
Which
of the following is an antifungal drug that acts by inhibiting fungal DNA
synthesis?
a.
|
c
|
|
74.
|
Which
of the following antimycobacterial drugs is inactivated by hepatic
acetylation, the rate of which depends on genetic background?
a.Streptomycin b.Ethambutol c.Rifampin d.Isoniazid
|
d
|
|
75.
|
Which
antibiotic cause cartilage damage in children
a.Sulphonamide b. Cephalosporin c.Ampicillin d.Ciprofloxacin
|
d
|
|
76.
|
Which
one of the antibiotic is safe during pregnancy
a.Gentamicin b. Ciprofloxacin c.Cefuroxime d.Chloramphenicol
|
c
|
|
77.
|
Select
the false
a.Aminoglycoside
and flouroquinolone both are greater effective in alkaline pH.
b.Aminoglycoside
and flouroquinolone both are highly active against gram negative bacteria as
compare to gram positive bacteria.
c.Aminoglycoside
and flouroquinolone both are less active in acidic pH.
d.Aminoglycoside
and flouroquinolone both shows concentration dependent action and long post-antibiotic
effect.
e.Aminoglycoside
and flouroquinolone both possess good tissue penetrability property.
|
e
|
|
78.
|
Match
the following
a.Pyrimethamne
/trimethprim 1. Macrocytic/megaloblastic anemia
b.Isoniazid
2. Siderblastic anemia
c.Chloramphenicol 3.
Aplastic anemia
d.Methotexate 4. Haemolytic anemia
e.
Dapsone
choose
right option:
a.A-1,b-2,c-3,d-4,
e-4 b.a-1,
b-2, c-3, d-3, e-4
c.a-1,b-3,c-2,d-1,e-4 d.
a-1,b-3,c-2,d-3, e-4
|
a
|
|
79.
|
Highest
photosensitivity shown by which flouroquinoline antibiotic
a.Sparfloxacin b.Pefloxacin c.Levofloxacin d.Gatifloxacin
|
a
|
|
80.
|
Which
anti tubercular drug side effect is
Pseudo jaundice
a.Rifampicin b.Rifabutin c.Isoniazid d.Ethambutol
|
b
|
|
81.
|
Drug
effective in Avian influenza
a.Oseltamivir b.Amantadine c.Zidovidine d. All
|
a
|
|
82.
|
Match
the following
a.NRTI Antiretroviral drug 1. Pancreatitis and peripheral
neuropathy
b.
Integrase inhibitor drug 2. Raltregravir
c.
Ketoconazole
3. Adrenal insufficiency
d.
Amphotericin-B
4. Hypokalemia
correct:
a.a-1,b-2,
c-3,d-4 b.a-3,b-2,c-1,d-4
c.a-4,b-2,c-3,
d-1 d.a-1,b-2,c-4,d-3
|
a
|
|
83.
|
Drug
which is useful in isoniazid poisioning
a.Bicarbonate b.Pyridoxine c.Diazepam d.All
|
d
|
|
84.
|
Select
the wrong statement about gresiofulvin
1.Its
absorption increased by both ultra fining of particle and by fat
2.It
is systemically used for topical fungal infection
3.Its
is effective against topical infection like tinea capitis, tinea cruris,
tinea pedis but not effective against tinea versicolor
4.It
interfere with mitosis
5.Deposited
in hair and skin
6.It
inhibit ergosterol synthesis
a.
3 b.6 c.3 and 6 d.all are true
|
b
|
|
85.
|
Which
set of approximate bond angles at C1, C2 and N of the following molecules
indicates the correct shape?
a. C1: 120˚; C2: 120˚; N: 120˚
b. C1: 109˚.28”; C2: 120˚; N: 109˚.28”
c. C1: 109˚.28”; C2: 120˚; N: 120˚
d. C1: 120˚; C2: 109˚.28” N: 109˚.28”
|
d
|
|
86.
|
Arrange the following
according to increase in Bond energy.
a. C-H > C-C > H-H
> C-Cl
b. H-H > C-H > C-C > C-Cl
c. C-Cl > C-C > C-H > H-H
d. C-C> H-H > C-H> C-Cl
|
b
|
|
87.
|
Which set of hybridization states of C1, C2 and C3 of the
following molecule is correct?
a. C1: sp2; C2: sp2; C3: sp2
b. C1: sp2; C2: sp2; C3: sp
c. C1: sp3; C2: sp2; C3: sp
d. C1: sp3; C2: sp2; C3: sp2
|
a
|
|
88.
|
Which species contains a sp3 hybridized atom?
a. H2C = CH2
b. H2C = O+H
c. H3O+
d. H2C = NH
|
c
|
|
89.
|
Geometry of Carbon in tetrahedral symmetry shown by which type
of hybridization?
a. sp2
b. sp
c. sp3
d. sp3d
|
c
|
|
90.
|
Which set of approximate bond angles at C1, C2, and N of the
following molecules indicates the correct shape?
a. C1: 120˚; C2: 120˚; N: 120˚
b. C1: 120˚; C2: 120˚; N: 109˚.28”
c. C1: 109˚.28”; C2: 120˚; N: 120˚
d. C1: 120˚; C2: 109˚.28”; N: 109˚.28”
|
a
|
|
91.
|
Which one having the greater bond length?
a. H3C – CH3
b. H2C = CH2
d. C – Cl
|
c
|
|
92.
|
Identify the false
statement regarding resonance.
a. As the no. of charges increases, the resonance forms gets
more significant.
b. Zero charge of resonance is the most significant one.
c. Atoms with full octet resonance form are more stable when
compared with one with unfilled octet.
d. Resonance is unstable in case of unfilled octet of nitrogen
atom.
|
a
|
|
93.
|
Identify the correct sequence with respect to inductive effect.
a. CF3 > CH2F > CHF2 >
CF3
b. CF3 > CHF2 > CH2F >
CH3
c. CH3 > CH2F > CHF2 >
CF3
d. CH3 > CHF2 > CH2F >
CF3
|
b
|
|
94.
|
In which of the following
hydrogen bond is strongest?
a. HI
b. HCl
c. H2O
d. H2S
|
c
|
|
95.
|
ENL(erythromanodulosumleprosum)
is a side effect of ?
a.Dapsone b.Clofazimine c.Chloquine d.rifampine
|
a
|
|
96.
|
toxic
metabolite of INH is ?
a.n acetyl
hydrazine b.n methyl hydrazine c.n acetyl- n phenyl hydrazine
d.n-acetyl-l-
arginine dihydrazine
|
a
|
|
97.
|
green stool is
aside effect of which antiamobiac drug?
a.Diloxanide b.Iodoquinine c.Metronidazole d.Ornidazole
|
b
|
|
98.
|
Which of the
antimicrobials obtained from actinomyctes?
a.Aminoglycoside b.Polyenes c.Teyracycline d.All of above
|
d
|
|
99.
|
Erythromycin
may not administered as
a.Succinate
salt b.Sterate salt c.Steolate salt d.Sulphate salt
|
d
|
|
100.
|
Intradermal
testing is required for which antimicrobial before administration?
a.Doxycycline b.Gentamicin c.Penicillin G d.azithromycine
|
c
|
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