Target GPAT-2018 General Pharmacology Series- 4

1. which of the following is a type b (unpredictable) adverse drug reaction: a. side effect b. toxic effect c. idiosyncrasy d. physical dependence	C
2. drugs producing allergic reactions generally act as: a. complete antigens b. haptenes c. antibodies d. mediators	B
3. which of the following is the only life saving measure in case of anaphylactic shock: a. intravenous hydrocortisone hemisuccinate b. intravenous chlorpheniramine maleate c. intramuscular adrenaline hydrochloride d. intravenous glucose-saline	C
4. intradermal drug sensitivity tests can detect the presence of following type of hypersensitivity: a. type i (anaphylactic) b. type ii (cytolytic) c. type iii (retarded) d. all of the above	a
the most vulnerable period of pregnancy for the causation of foetal malformations due to drugs is: a. 18-55 days of gestation b. 56-84 days of gestation c. second trimester d. 36 weeks onwards	A
functional proteins that are target of drug action i.enzymes ii.transporters iii.ion channels iv.receptors correct a.i,ii,iii b.ii,iv c.i,ii d.i,ii,iii,iv	D
5. which of the following drug is a competitive inhibitor of enzyme but non equilibrium type a.physostigmine compete with acetycholine for cholinesterase b.sulfonamide compete with paba for bacterial folate synthase c.allopurinol compete with hypoxanthenes for xanthine oxidase d.organophosphate compete with acetylcholine for cholinestrase	D
6. which of the following drug is not a non competitive inhibitor of enzyme a.acetazolamide inhibit carbonic anhydrase b.disulfiram inhibit aldehyde dehydrogenase c.digoxin inhibit na k atpase d captopril inhibit ace enzyme	D
7. select the drug act through  ion channel a.ethosuximide b.amiloride c.both a nd b d.none of these	C
select the drug act through transporters i.fluoxetine ii.phenytoin iii.furosemide iv.desipramine correct a.i,ii,iii b.i,iii,iv c.ii,iii,iv d.i,ii,iii,iv	b
select the wrong statement a.competitive antagonist have high affinity  and high intrinsic activity b.partial agonist have affinity and sub maximal intrinsic activity c.inverse agonist have affinity but intrinsic activity with a minus sign d.agonist have both high affinity and maximal intrinsic activity	A
8. select the partial agonist a.naloxone b.pentazocine c.atropine d.morphine	B
9. select the competitive antagonist a.propranolol b.atropine c.naloxone d.all of these	D
10. select the following which act through enzyme linked receptors a.insulin b.epidermal growth factor c.both of these d.gaba-a	C
11. which of the following is ion channel receptor i.gaba,glycine ii.nmda,5-ht3 iii.nicotinic cholinergic iv.5-ht1,dopamine correct a.i,ii,iii,iv b.i,ii,iii c.ii,iii,iv d.i,ii,iv	b
12. which of the following is a g protein coupled receptor, act through ip3 dag pathway a.muscarinic-1 b.muscarinic-2 c.muscarinic-3 d.all a,b,c e. both a and c	e
13. histamine is a g coupled protein receptor,which of the following statement is true a.h-2 act through adenylyl cyclase pathway by increasing camp b.h-1 act through ip3 dag pathway c. h-2 act through adenylyl cyclase pathway by decreasing camp d.both a  and b	d
14. select the ligand act through ip3 dag pathway(gpcr) a.5-ht2 b.5-ht1 c.5-ht3 d.all of these	a
15. vit-a and d act through a.gpcr b.ion channel c.nuclear receptor d.enzyme linked receptor	c
16. select the intracellular receptor  a.gpcr b.ion channel c.nuclear receptor d.enzyme linked receptor	c
17. A receptor which itself has enzymatic property is: a. insulin receptor b. progesterone receptor c. thyroxine receptor d. glucagon receptor	a
18. ‘drug efficacy’ refers to: a. the range of diseases in which the drug is beneficial b. the maximal intensity of response that can be produced by the drug c. the dose of the drug needed to produce half maximal effect d. the dose of the drug needed to produce therapeutic effect	b
19. which of the following is always true: a. a more potent drug is more efficacious b. a more potent drug is safer c. a more potent drug is clinically superior d. a more potent drug can produce the same response at lower doses	d

Target GPAT-2018 General Pharmacology Series-3

41	which of the following statement is correct i.erytromycin,ampicillin,rifampin, attain high concentation in bile ii.lithium,rifampin secreted in saliva and sweat iii.basic drugs are more concentrated in milk as compare to acidic drugs iv.acidic drugs are more concentrated in milk as compared to basic drugs right statement is a.i,ii,iii b.i,ii,iv c.ii,iii only d.i,ii only	a
42	which of the following drugs is most likely to be absorbed from the stomach: a. morphine sulfate b. diclofenac sodium c. hyoscine hydrobromide d. quinine dihydrochloride	b
43	which of the following is a weakly acidic drug: a. atropine sulfate b. chloroquine phosphate c. ephedrine hydrochloride d. phenytoin sodium	d
44	the blood-brain barrier, which restricts entry of many drugs into brain, is constituted by: a. p-glycoprotein efflux carriers in brain capillary cells b. tight junctions between endothelial cells of brain capillaries c. enzymes present in brain capillary walls d. all of the above	d
45	weakly acidic drugs: a. are bound primarily to alpha 1 acid glycoprotein in plasma b. are excreted faster in alkaline urine c. are highly ionized in the gastric juice d. do not cross blood-brain barrier	b
46	which of the following cytochrome p450 isoenzymes is involved in the metabolism of largest number of drugs in human beings and has been implicated in some dangerous drug interactions: a. cyp 3a4/5 b. cyp 2c9 c. cyp 2e1 d. cyp 1a2	a
47	which of the following cytochrome p450 isoenzymes is involved in the metabolism of  2nd largest number of drugs in human beings a. cyp 3a4/5 b. cyp 2d6 c. cyp 2e1 d. cyp 1a2	b
48	the plasma half life of penicillin-g is longer in the new born because their: a. plasma protein level is low b. drug metabolizing enzymes are immature c. glomerular filtration rate is low d. tubular transport mechanisms are not well developed	d
49	when the same dose of a drug is repeated at half life intervals, the steady-state (plateau) plasma drug concentration is reached after: a. 2–3 half lives b. 4–5 half lives c. 6–7 half lives d. 8–10 half lives	b
50	monitoring plasma drug concentration is useful while using: a. antihypertensive drugs b. levodopa c. lithium carbonate d. mao inhibitors	c
51	a partial agonist can antagonise the effects of a full agonist because it has: a. high affinity but low intrinsic activity b. low affinity but high intrinsic activity c. no affinity and low intrinsic activity d. high affinity but no intrinsic activity	a
52	when therapeutic effects decline both below and above a narrow range of doses, a drug is said to exhibit: a. ceiling effect b. desensitization c. therapeutic window phenomenon d. nonreceptor mediated action	c
53	which of the following is always true: a. a more potent drug is more efficacious b. a more potent drug is safer c. a more potent drug is clinically superior d. a more potent drug can produce the same response at lower doses	d
54	if the effect of combination of two drugs is equal to the sum of their individual effects, the two drugs are exhibiting: a. potentiation b. synergism c. cross tolerance d. antagonism	b
55	the antidotal action of sodium nitrite in cyanide poisoning is based on: a. physical antagonism b. chemical antagonism c. physiological antagonism d. noncompetitive antagonism	b
56	the following is a competitive antagonist of gaba but a noncompetitive antagonist of diazepam: a. picrotoxin b. muscimol c. flumazenil d. bicuculline	d
57	fixed dose combination formulations are not necessarily appropriate for: a. drugs administered in standard doses b. drugs acting by the same mechanism c. antitubercular drugs d. antihypertensive drugs	b
58	which adverse drug effect is more common in children than in adults: a. isoniazid induced neuropathy b. chlorpromazine induced muscle dystonia c. digoxin induced cardiac arrhythmia d. penicillin hypersensitivity	b
59	the following drug adverse effect is specially noted in men compared to women: a. tardive dyskinesia due to neuroleptics b. levodopa induced abnormal movements c. ampicillin induced loose motions d. ketoconazole induced loss of libido	d
60	which of the following adverse drug reactions is due to a specific genetic abnormality: a. tetracycline induced sunburn like skin lesions b. quinidine induced thrombocytopenia c. metoclopramide induced muscle dystonia d. primaquine induced massive haemolysis	d