AUTONOMIC NERVOUS SYSTEM MCQS-3

1.	which of the following show reactivation of  cholinestrase but does not involve hydrolysis of cholinestrase(inhibitor) a.tacrine         b.edrophonium       c.both               d.neostigmine	c
2.	the choline ester hydrolysed by true cholinesterase but not by pseudocholinesterase is: a. methacholine      b. bethanechol     c. acetylcholine         d. carbacol	a
3.	the anticholinesterase action of edrophonium is short lasting because termination of its action depends on: a. dissociation and diffusion of the drug from the enzyme b. hydrolysis of the drug by the enzyme c. synthesis of fresh enzyme molecules d. a combination of the above three processes	a
4.	the organophosphates produce irreversible inhibition of cholinesterase because: a. they bind to an allosteric site of the enzyme resulting in unfavourable conformation of esteratic site to bind acetylcholine b. regeneration time of the phosphorylated enzyme is longer than the turnover time of the enzyme molecules c. phosphorylation results in rapid degradation of enzyme molecules d. they are neither metabolized nor excreted from the body	b
5.	pilocarpine is obtained from a.leaves of pilocarpus microphyllus      b.roots of pilocarpus microphyllus c.stem of pilocarpus microphyllus        d.flower of pilocarpus microphyllus	a
6.	which of the following is a physiological antagonist of ach a.adrenaline        b.atropine                 c.both                     d.none	a
7.	select the lipid insoluble anticholinestrase a.physostigmine      b.neostigmine         c.organophosphate      d.donepezil	b
8.	currently, the first choice drug for open angle glaucoma is: a. miotic eye drops                                  b. ocular alpha 2 adrenergic agonists c. ocular prostaglandin analogues          d. ocular beta adrenergic blockers	d
9.	in miosis a.contraction of circular or sphincter papillae b.relaxation of radial or dilator papillae c.both of these                               d.given statement is not complete	c
10.	pyridostigmine differs from neostigmine in that: a. it is more potent orally                              b. it is longer acting                   c. it produces less muscarinic side effects d. it does not have any direct action on nm receptors	b
11.	myasthenia gravis is a auto immune disease i.it occur due to development of antibody against nicotinic receptors(nm) ii.treatment is usually started with neotigmine but half life is short iii.pyridostigmine is an alternative which needs less frequent dosing due to long half life iv.this disorder affect 1000 in 10000 people correct statement a.i,ii,iv            b.i,ii,iii                 c.ii,iii,iv                      d.i,ii,iii,iv	b
12.	edrophonium is more suitable for differentiating myasthenic crisis from cholinergic crisis because of its: a. shorter duration of action                            b. longer duration of action c. direct action on muscle end-plate d. selective inhibition of true cholinesterase	a
13.	in belladonna poisioning which specific antidote is used a.atropine sulphate i.v                              b.physostigmine i.v c.both of these                                         d.no specific antidote available	b
14.	physostigmine absorbed through a.g.i.t            b.parenteral site              c.cornea                  d.all of these	d
15.	about neostigmine which of the following is true a.they are easily absorbed through git       b. not effectvely penetrate cornea c.easily cross bbb                                       d.all of these	b
16.	which statement is  not correct about organophosphate a.they are lipophilic                     b.they are easily absorbed through skin c.reversible cholinesterase           d.all of these	d
17.	select true statement a.neostigmine is natural but physostigmine is synthetic b. neostigmine is synthetic but physostigmine is natural c. neostigmine and physostigmine both are synthetic d. neostigmine and physostigmine both are natural	b
18.	wrong statement a.physostigmine is a tertiary amine derivative b. physostigmine used as a miotic c.neostigmine is a quaternary ammonium compound d. neostigmine is not used in myasthenia gravis	d
19.	timolol eye drops are preferred over pilocarpine eye drops by glaucoma patients because: a. timolol is more effective than pilocarpine b. timolol acts by enhancing uveo-scleral outflow c. timolol produces less ocular side effects d. there are no contraindications to timolol	c
20.	which anti cholinesterase drug is not used for alzheimer disease a.neostigmine            b.tacrine           c.rivastigmine             d.donepezil	a

AUTONOMIC NERVOUS SYSTEM MCQS-2

1.	select the odd one a) tubocurarine     b) nicotine in high dose    c) hexamethonium      d) trimethophan	A
2.	the drug not used by sportsman for anabolic effect is a) amphetamine     b) nandrolol               c) stenazalol                   d) labetolol	D
3.	Beta blockers are contraindicated in a) glaucoma           b) anxiety                  c) asthma                        d) hyperglycemia	C
4.	the Beta blocker used chiefly in glaucoma is a) propanolol        b) timolol                    c) metoprolol                 d) labetolol	B
5.	Cocaine is a sympathetic agent. Act by a) block NA uptake from nerve ending                             b) beta agonist        c) prevent NA release                                                        d) beta blocker	A
6.	the drug having higher first pass effect is a) nadolol                   b) sotalol                     c) atenolol                   d) propanolol	D
7.	Ergot alkaloids are a)      alpha, 5-HT partial agonist, beta blockers b)      alpha, 5-HT blockers, beta agonist c)      alpha, beta agonist, 5-HT blockers d)      alpha, 5-HT, beta agonists	A
8.	the receptor whose agonists are used by sportsman for anabolic effect is a) α1                         b) α2                                c) β1                                 d) β2	A
9.	which gland or organ receive only sympathetic innervation i.spleen        ii.sweat gland          iii.hair follicles        ivciliary muscle correct a.i,ii,iii           b.ii,iii,iv               c.i,iii,iv               d.i,ii,iii,iv	A
10.	which gland or organ receive only parasympathetic innervation i.pancreatic gland        ii.sweat gland    iii.hair follicles     ivciliary muscle correct      a.i,ii         b.ii,iii,iv      c.i,iv                        d.i,ii,iii,iv	C
11.	the cotransmitter may serve the following function: a. regulate the release of the primary transmittermfrom the nerve ending b. alter postjunctional action of the primary transmitter c. itself act as an alternative transmitter              d. all of the above	d
12.	select wrong statement(during synthesis of acetylcholine) a.choline is taken up by axonal membrane by a na :choline cotransporter b.no energy requirement during uptake of choline c.acetylation process occur during synthesis of ach in presence of choline acetyl transferase d.hemicholinium inhibit uptake of choline	b
13.	the choline ester resistant to both true and pseudocholinesterase is: a. methacholine    b. bethanechol   c. benzoylcholine     d. butyrylcholine	b
14.	butylcholinestrase not distributed at a.all cholinergic sites     b.liver         c.plasma           d.white matter	a
15.	select antagonist at m1 receptor a.oxotremorine       b.mcn-343a           c.pirenzepine     d.all of these	c
16.	which of the following secretions is not stimulated by acetylcholine: a. tear         b. bile        c. pancreatic juice              d. sweat	b
17.	pilocarpine is used for: a. glaucoma       b. paralytic ileus     c. urinary retention    d. all of the above	a
18.	the following inhibitor binds only to the ani-onic site of the cholinesterase enzyme: a. neostigmine     b. physostigmine    c. edrophonium         d. dyflos	d
19.	reactivation of cholinesterase enzyme occurs on hydrolysis of the inhibitor by the same enzyme molecule in case of the following anticholinesterase: a. edrophonium    b. neostigmine     c. dyflos              d. tacrine	b
20.	organophosphate bind to which site of cholinestrase a.anionic site          b.esteric site            c.both of these          d.none	b