GPAT- 2018 TEST NUMBER- 1

1.	Time: 1 hour       GPAT ADDA ACADEMY   Test Series.-1  I CAN AND I WILL……… TOTAL QUESTION-100  Add.- Vinayak complex, D-park, rohtak, contact no. 8901408422, 9671935154  Which of the sulphonamide is a prodrug A.sulfadiazine      b.sulfadoxine    c.sulfasalazine     d. All of these	C
2.	Which sulphonamide is short acting A.sulfadoxine     b.sulfamethopyrazine     c.sulfamethoxazole  d.sulfadiazine	D
3.	Which of the sulphonamide is topically used A.mafenide   b.sulfacetamide sodium   c.both of these   d.sulfadiazine	C
4.	Sulfamethoxazole was selected for combining with trimethoprim because A.both have same half life       b.both adequately cross blood brain barrier C.both a and b                        d. None of these	A
5.	Fluoro quinolones are A. natural    b. Semisynthetic     c. Synthetic    d.natural+semisynthetic	C
6.	Methyl derivative of norfloxacin is A.ofloxacin    b.pefloxacin    c.ciprofloxacin    d.sparfloxacin	B
7.	Most potent fluoro quinolones is A. Ofloxacin    b.pefloxacin    c.ciprofloxacin    d.norfloxacin	C
8.	Name the penicillin resistant to both penicillinase and acid A.penicillin – v      b.methicillin     c.ampicillin      d.cloxacillin	D
9.	Extended spectrum penicillin A.penicillin – v      b.methicillin     c.ampicillin      d.cloxacillin	C
10.	Beta lactamase inhibitors A.sulbactam    b.mezlocillin     c.carbenicillin      d.both a and c	A
11.	Sulphonamide side effect A.jarisch herxheimer reaction    b.stevens johnoson syndrome C.both of these                           d.hallucinations	B
12.	Diabetes insipidus is caused by which tetracycline A.oxytetracyclin    b.doxycycline    c.minocycline    d.demeclocycline	D
13.	Diarrhoea is side effect of tetracycline,,,decrease in incidence of diarrhoea by using which tetracycline A.tetracycline    b.doxycycline    c.oxytetracycline       d.demeclocycline	B
14.	Which tetracycline is semisynthetic A.doxycycline    b.minocycline   c.both of these     d.none of these	C
15.	Which preparation of tetracycline banned A.dry syrups    b.liquid oral preparations    c.both of these     d.none of these	C
16.	Tetracycline are not recommended by which route A.i.m.    B.intrathecally  c.oral   d.both a and b	D
17.	Tetracyclins have chelating property with A.calcium   b.milk     c. Both of these  d.none of these	C
18.	Chloramphenicol is obtained from A.streptomyces chrysogenum   b.streptomyces notatum    C.sterptomyces venezuelae       d.all of these	C
19.	Adverse effect of chloramphenicol A.grey baby syndrome b.fancony syndrome c.both of these d.tin tin syndrome	A
20.	Which prodrug of chloramphenicol is soluble A. Chloramphenicol palmitate    b. Chloramphenicol succinate C.both of these                           d.none of these	B
21.	Red man syndrome is caused by A.erythromycin     b.vancomycin    c.clindamycin     d.all of these	B
22.	Vancomycin act by inhibiting A.cell wall synthesis     b.protein synthesis    c.both of these    d.DNA gyrase	A
23.	Which of the following is a prodrug A.sulfasalazine      b.isoniazid      c.both a and b      d.none of these	C
24.	Chloramphenicol inhibit protein synthesis by by binding at ribosome A.30s     b.50s   c.30 and 50     d.either 30 or 50	B
25.	Sulphonamide is sterilised by A.hot air ovan     b. Moist heat sterilisation   c. Tyndallisation  d. Gamma rays	A
26.	Which of the following is used for the extraction of antibiotic A.abc extractor      b. Rotary extractor    c.  Podbielnaik extractor    D. Whitle extractor	C
27.	Which of the following is the precursor of penicillin A.l-tryptophan    b. Phenyl acetic acid         c. Tyrosine      d.  L- dopa	B
28.	Which of the following technique is used for purification of streptomycin A.ion exchange   b. Reverse osmosis   c.  Both a and b    d. None	A
29.	Name the acidic drug A.novobiocin  b. Erythromycin  c. Streptomycin  d.  None of the above	C
30.	Murein content  in A.70-80% in gram +ve   b. 70-80% in gram -ve   C. 10-20% in gram +ve  d. None of these	A
31.	Teichoic acid is present in A.gram +ve      b. Gram –ve    c. Brucellosis   d. All of these	A
32.	Endotoxin is produced by A.lysozyme  b. Gram +ve    c. Gram –ve  d. All of these	C
33.	Toxicity of endotoxin is due to A.lipid a     b.  Lipid b  c. Lipid o   d. None of these	A
34.	Structural component which is unique to gram –ve  (of outer membrane) is A.polysaccharide    b. Lipopolysaccharide        c.glycopolysaccharide   D.mycolic acid	B
35.	Which of the following is gram –ve bacteria A.bacillus anthracis                        b.clostridium tetani  C.staphylococcus aureus                d.salmonella typhi	D
36.	Which of the following is gram +ve bacteria A.vibrio cholera                              b.e. Coli   C.cornybacterium diphtheria         d. Neisseria gonorrhoeae	C
37.	Dust borne infection is A.diphtheria     b. Typhoid   c. Both of these  d.none of these	D
38.	Which beta lactam antibiotic shows least hypersensitivity reaction a.       Penicillin     b. Aztreonam    c. Cephalosporin      d. Carbapenem b.	B
39.	Which of the carbapenem degraded by dehydropeptidase a.       Meropenem     b. Imipenem      c. Doripenem        d. All of these b.	B
40.	Which of the following have no antibiotic effect a.       Monobactam     b. Clavulanic acid     c. Both a and b     d. None b.	B
41.	Select the very low therapeutic index drug a.       Beta lactam antibiotic     b. Vancomycin      c. Both a and b    d. None b.	B
42.	Select the true for tetracycline a.       Highly phototoxic tetracycline                1.doxycycline     b.      Semisynthetic tetracycline                      2.demeclocycline c.       Safer tetracycline   in liver damage         3.minocycline d.      Highly potent tetracycline                         4.oxytetracycline a.       A-1, 2-b,3-c, 4-d           b. A-2, b-1, c-4, d-3 C.a-1,b-2, c-3, d-4         d. A-1, b-2, c-4, d-3	B
43.	Which is not Degraded product of tetracycline a.       Epitertacycline       b. Chlotertacycline      c.anhydrotetracycline      e.       Epianhydrotetracycline	B
44.	Cilastatin drug used with a.       Imipenem    b. Doripenem         c.meropenem     d. All b.	A
45.	Fifth  generation cephalosporin used by a.       Orally      b.parentrally     c. Both       d.none b.	B
46.	Which drug is ist generation cephalosporin a.       Cefaclor       b. Cefuroxime        c. Cefepime        d. Cefadroxil b.	D
47.	Which of the following is prodrug a.       Amoxicillin     b.benzathine penicillin      c. Talaampicilline    d. None b.	C
48.	Select bacteriocidal drug a.       Sulphonamide       b. Tetracycline    c. Aztreonam       d.all	C
49.	Fluoroquinolone drug which prolong QT interval  (cardiac arrythmia) a.       Gatifloxacin       b. Ciprofloxacin      c. Ofloxacin    d. All b.	A
50.	Longest acting fluoroquinolone a.       Ciprofloxacin      b. Ofloxacin     c.sparfloxacin        d.all    b.	C
51.	Cross resistance example a.       Sulphamethoxazole      and    sulfadiazine b.      Oxytertacycline      and demeclocycline c.       Erythromycin and clindamycin d.      Tetracycline    and chloramphenicol e.       All of these f.       Both c and d g.	E
52.	Concentration dependent antibiotic effect a.       Gentamicin   b. Quinolones    c. Aminoglycoside     d. All    e. Both a and b	D
53.	Time  dependent antibiotic effect a.       Gentamicin     b. Quinolones    c. Beta lactam    d. All	C
54.	international pharmacopoeia is published by A  AICTE              B UGC                C GMP                         D WHO	D
55.	what is proportion of oil, water, and gum acacia for fixed oil A   4:2:1                   B 2:2:1                  C 3:2:1               D 2:4:1	A
56.	The new edition of IP is published after every A 4 year                    B 5 year                C 6 year           D 3 year	D
57.	At what temp the blood is strored A 15◦c                       B 4◦c                     C   0◦c               D 10◦c	C
58.	the first edition of Indian pharmacopoeia is published in the year A 1940          B 1985             C 1955                 D 1950	C
59.	which is known as BAL (British anti-lewisite) A diamecaprol      B carbon dioxide        C magnesium oxide    D calcium oxide	A
60.	Drugs in suspensions and semi-solid formulations always degrade by a    first order kinetics   b     second order kinetics c    zero order kinetics  d   non-linear kinetics	C
61.	Ratio of oil: water: gum, if oleo-resins is using in making emulsion a     2 : 2 : 1                b     3 : 2 : 1          c    4 : 2 : 1          d     None of above	A
62.	Ratio of oil: water: gum, if code liver oil is using in making emulsion a     2 : 2 : 1          b     3 : 2 : 1         c    4 : 2 : 1            d     None of above	C
63.	the 5th edition of Indian pharmacopoeia is published in the year  A 2002         B 2010              C 2007                              D 2012	C
64.	According to IP 1996 temperature range of injection streptomycin sulphate A      -4 ◦c             B     -2  ◦c          C     -8◦c                          D     -15◦c	A
65.	According to (USP 1995) temperature rang cool places? A   8-25◦c               B  2-8 ◦c               C  8-15 ◦c                          D  10-15◦c	C
66.	According to IP 1996 temperature range of heparin injection A       -10◦c            B      -15  ◦c        C    -20  ◦c                    D     -8 ◦c	B
67.	What is blood ph A      7.2           B      7.4      C    7.5                  D     7.1	C
68.	Most of drugs follow which order? A      first order          B      zero order       C    pseudo order                   D     mixed order	A
69.	Suspensions OR semisolid dosage forms which order follow?   A      first order          B      zero order       C    pseudo order                   D     mixed order	B
70.	When a drug absorption in body how many half life required? c  A      4          B      7      C    5                 D     3	C
71.	The dye used to  give desired color to cosmetics should be approved by A FDA            B FD & C               C both a & b                                  D WHO	B
72.	What is range of ph of vehicle in formulating nasal drops? A 5.5- 7.5            B 5.1-7.1              C 5.1-7.8               D 5.1-7.8	A
73.	Fennel contains type of stomata: a  Diacytic       b  Actinocytic                     c Anisocytic        d Anomocytic	D
74.	Cinnamom bark does not contain: a)  Cinnamaldehyde    b)  Tannins           c)  Coumarin         d)  Benzaldehyde	C
75.	The chemical name of guanine is (A) 2,4-Dioxy-5-methylpyrimidine               (B) 2-Amino-6-oxypurine (C) 2-Oxy-4-aminopyrimidine                       (D) 2, 4-Dioxypyrimidine	B
76.	The sugar moiety present in DNA is (A) Deoxyribose          (B) Ribose            (C) Lyxose           (D) Ribulose	A
77.	Which is not used as an adulterant for clove? a)  Mother clove        b)  Blown clove        c)  Clove stalk     d)  Pale clove	D
78.	Match the following tests with their respective applications A to E: 1. Schick test                 A. Tuberculosis 2. Mantoux test               B. Detection of extraneous microorganisms 3. Sterility test                 C. Diphtheria toxin 4. Potency test                D. Usefulness of immunological products Select a.1-c,2-a,3-b,4-d          b.1-a,2-c,3-b,4-d c.1-c,2-a,3-d,4-b          d.1-a,2-c,3-d,4-b	a
79.	In autoclave, the principle involved is a. Dry heat                b. Moist heat       c. Steam under pressur   d. Both b and c	d
80.	The penicillin produced in large scale submerged fermentations are a. Penicillin-A          b. Penicillin-D     c. Penicillin-G          d. None of these	C
81.	The strain of fungi used for the large scale production of penicillin is a. Penicillium chrysogenum     b. P-notatum c. Streptomyces Aurecus         d. Saccharomyces sps	A
82.	Vitamin B12 can be estimated and determined by using organism a. Lactobacillus sps                b. Lactobacillus Leichmanni c. Bacillus subtilis                    d. E.Coli	B
83.	Example for live vaccine is a. Rubella & BCG               b. Polio & TAB c. Diphtheria & Tetanus     d. Hepatitis A & Rabies	A
84.	Vaccines are prepared from killed microbes, they are a. Inactivated (killed) vaccine   b. Attenuated vaccines  c. Autogenous vaccine           d. None of these	A
85.	Immunoglobulin is associated with anaphylactic delayed hypersensitivity reaction a. IgE                     b. IgA            c. IgD               d. IgM     e. IgG	A
86.	Killed, polio vaccine is a. Sabin vaccine       b. Salk           c. BCG                  d. TAB	A
87.	Antigen-antibody reactions are a. Reversible              b. Irreversible     c. Specific                   d. Both a and b	D
88.	The protein moiety of an enzyme is known as a. Holo enzyme     b. Apo enzyme      c. Co enzyme        d. Enzyme	B
89.	Bacteria which need oxygen for growth are called a. Thermophilic bacteria                  b. Microaerophilic bacteria c. Facultative anaerobic bacteria     d. Mycobacteria	B
90.	The enzymes which are commonly used in genetic engineering are a. Exonuclease and ligase b. Restriction endonuclease and polymerase c. Ligase and polymerase d. Restriction endonuclease and ligase	A
91.	DNA transfer from one bacterium to another through phages is termed as a. Transduction            b. Induction      c. Transfection                    d. Infection	A
92.	Lyophilization is also known as : (a) Drying by sublimation                     (b) Freeze drying (c)Both a and b                                      (d) none	C
93.	Triple roller mill is used in mixing of: (a) semi solids (b) solids     (c) liquids       (d) none of these	A
94.	Endotoxin are: (a) Class of pyrogen                                                 (b) Lipopolysaccrides in nature (c) Componets of cell wall of gram negative bacteria                 (d)all	D
95.	Water for injection : (a)does need to be sterile (b) Conductivity should not  >1 micromho (C) purified by distillation or two stage reverse osmosis (d) all of above	D
96.	In dry milling moisture should not be less than: (a) 2           (b) 3%              (c) 2%             (d) 10%	A
97.	Adulterants for clove              Characteristics a)         Mother clove               i)          Expanded flowers of clove trees. b)         Blown cloves              ii)         Contain only 5% of oil. c)         Clove stalks                 iii)        Oil is removed from clove. d)         Exhausted clove          iv)        iv)        Dark brown, ovate and ripened                                                                         Fruits of clove A)  a) iv           b) i.      c) ii      d) iii      C) a) iv                b) ii. c) iii    d) i      B)  a) iv           b) i.      c) iii     d) ii       D) a) i            b) iv.    c) ii      d) iii	A
98.	The family of Ocimum sanctum: a)  Labiatae                 b)  Liliaceae         c)  Lauraceae      d)  Loganaceae	A
99.	Which of the following is a non-reducing sugar? (A) Isomaltose (B) Maltose             (C) Lactose            (D) Trehalose	D
100.	The sugar found in milk is (A) Galactose               (B) Glucose            (C) Fructose          (D) Lactose	D