PHARMACOLOGY: PHARMACOKINETIC MCQS

1.	Most common conjugation reaction for drugs: A. Glucuronidation B. Acetylation and Methylation C. Glutathione conjugation D. cyclization E.  both b and c	A
2.	Microsomal enzyme induction can cause: A. Tolerance B. Physical dependence and Psychological dependence C. hypersensitivity reaction D. Idiosyncrasy E. both a and b	A
3.	Drug metabolizing reaction which is entirely nonmicrosomal: A. Glucuronide conjugation B. Acetylation C. Oxidation D. Reduction E. both c and d	B
4.	drug metabolizing enzymes which are inducible: A. Microsomal enzymes B. Nonmicrosomal enzymes C. Both microsomal and nonmicrosomal enzymes D. Mitochondrial enzymes E. all of these	A
5.	Induction of drug metabolizing enzymes involves: A. A conformational change in the enzyme protein to favour binding of substrate molecules B. Expression of enzyme molecules on the surface of hepatocytes C. Enhanced transport of substrate molecules into hepatocytes D. Increased synthesis of enzyme protein	D
6.	Drug which shows highest first-pass metabolism in the liver of the following: A. Phenobarbitone B. Zidovudine  C. Phenylbutazone D. Propranolol	D
7.	High first-pass metabolism drugs in liver cause: A. low oral bioavailability B. drugs excreted primarily in bile C. show high protein binding D. Exhibit first order kinetics of elimination     E. both a and b	A
8.	Which of the following is microsomal enzyme inducer: A.    Phenobarbitone B.     Glucocorticoids C.     Rifampin D.    All	D
9.	Which of the following is microsomal enzyme inhibitor: a.       Quinidine b.      Allopurinol c.       Ketoconazole d.      Fluoxetine e.        all	E
10.	Which of the following drugs metabolism affected by hepatic blood flow: a.       Propranolol b.      Morphine c.       Verapamil d.      Imipramine e.       All	E
11.	Which of the following drugs metabolism is affected by enzyme induction: a.       Warfarin b.      Oral contraceptives c.       Chloramphenicol d.      Griseofulvin and theophylline e.       All	E
12.	Grape juice is: A.    Cyp3a4/5 microsomal enzyme inducer B.     Cyp3a4/5 microsomal enzyme inhibitor C.     Cyp2d6  microsomal enzyme inducer D.    Cyp2d6  microsomal enzyme inhibitor	B