PHARMACOLOGY: PHARMACOKINETIC MCQS

1.	Most common conjugation reaction for drugs: A. Glucuronidation B. Acetylation and Methylation C. Glutathione conjugation D. cyclization E.  both b and c	A
2.	Microsomal enzyme induction can cause: A. Tolerance B. Physical dependence and Psychological dependence C. hypersensitivity reaction D. Idiosyncrasy E. both a and b	A
3.	Drug metabolizing reaction which is entirely nonmicrosomal: A. Glucuronide conjugation B. Acetylation C. Oxidation D. Reduction E. both c and d	B
4.	drug metabolizing enzymes which are inducible: A. Microsomal enzymes B. Nonmicrosomal enzymes C. Both microsomal and nonmicrosomal enzymes D. Mitochondrial enzymes E. all of these	A
5.	Induction of drug metabolizing enzymes involves: A. A conformational change in the enzyme protein to favour binding of substrate molecules B. Expression of enzyme molecules on the surface of hepatocytes C. Enhanced transport of substrate molecules into hepatocytes D. Increased synthesis of enzyme protein	D
6.	Drug which shows highest first-pass metabolism in the liver of the following: A. Phenobarbitone B. Zidovudine  C. Phenylbutazone D. Propranolol	D
7.	High first-pass metabolism drugs in liver cause: A. low oral bioavailability B. drugs excreted primarily in bile C. show high protein binding D. Exhibit first order kinetics of elimination     E. both a and b	A
8.	Which of the following is microsomal enzyme inducer: A.    Phenobarbitone B.     Glucocorticoids C.     Rifampin D.    All	D
9.	Which of the following is microsomal enzyme inhibitor: a.       Quinidine b.      Allopurinol c.       Ketoconazole d.      Fluoxetine e.        all	E
10.	Which of the following drugs metabolism affected by hepatic blood flow: a.       Propranolol b.      Morphine c.       Verapamil d.      Imipramine e.       All	E
11.	Which of the following drugs metabolism is affected by enzyme induction: a.       Warfarin b.      Oral contraceptives c.       Chloramphenicol d.      Griseofulvin and theophylline e.       All	E
12.	Grape juice is: A.    Cyp3a4/5 microsomal enzyme inducer B.     Cyp3a4/5 microsomal enzyme inhibitor C.     Cyp2d6  microsomal enzyme inducer D.    Cyp2d6  microsomal enzyme inhibitor	B

Analysis Mcqs

1.	During titration of  0.1 M HCl with 0.1 M NaOH using indicator, what type of error occurs: a) Hydrogen error b) Hydroxyl error c) Acidic error d) Alkaline error e) all type	D
2.	In Glass electrode, platinum wire is inserted in which type of solution a) 0.1 M Hydrochloric acid b) 0.1 M Mercuric chloride c) 0.1 M Potassium chloride d) 0.1 M Potassium Bromide e) both a and b	A
3.	Absorption maxima goes to longer wavelength is called a) Hypochromic shift b) Hyperchromic shift c) Blue shift d) Red shift e) yellow shift	D
4.	Xenon arc lamp is source of a) Spectrofluoremeter b) IR Spectrometer c) UV-Visible Spectrophotometer d) NMR e) LC-MS	A
5.	Which of the following is unit of chemical shift: a) Centimeter b) cm-1 c) Part per million d) Cycle per second e) Mho	C
6.	In Polarography, diffusion current is effected by a) Nernest equation b) Ilkovic equation c) Handerson equation d) Gram equation e) all	B
7.	What is the unit of specific conductance? a)Ohm    b.Mho    c. Ohm cm-1 d. mho cm-1      e. none	D
8.	Diazotization titration is not used for a) Pyrimethamine b) Sulphadiazine c) Sulfamethoxazole d) Thiamine HCl e) none	d

pharmacologya and pharmacy mcqs

1	Mini Pill contains which component: a) Estrogen  b) estrogen and testosterone c) Progesterone d) Estrogen and Progesterone	C
2	After long time use of organic nitrates in Angina pectoris cause one of the following side effect a) liver damage  b) Tolerance c) Aplastic anemia d) kideney damage/Nepherotoxicity	B
3	Zafirleukast is used as anti-asthmatic; it is a) Prostaglandin antalogues b) Lipooxygenase Inhibitor c) Cyclooxygenase inhibitor d) Leukotrine receptor antagonist	D
4	Major cause of drug instability: a) Oxidation b) Photolysis and cyclization  c) Hydrolysis d) Racemization	A
5	Zeatin is: a) Auxin b) Ethylene c) Cytokinin d) Abscisic acid e) Gibberlin	C
6	Cap Aloe is a) Aloe Barbadensis b) Aloe Perryi c) Aloe Succotrina d) Aloe ferox e) Aloe vera	D
7	Most toxic constituent of Red Squill is a) Scillaren A b) Scillaren B c) Scilliroside d) Glucoscillaren e) both a and b	C
8	Rutin is rhamanoglucoside of a) Scopoletin b) Hesperitin c) Tropane d) Quercetin e) Apigenin	D
9	Castor oil is a) Non drying oil b) Semi drying oil c) Drying oil d) volatile oil	b
10	Animal wool fat is a) Fat b) Lipid c) Wax  d) Fixed oil e) oil	C