Target GPAT-2018- General Pharmacology Series-2

21	which of the following statements is correct? a. if 10 mg of drug a produces the same response as 100 mg of drug b, drug a is more efficacious than drug b. b. the greater the efficacy, the greater the potency of a drug. c. in selecting a drug, potency is usually more important than efficacy. d. a competitive antagonist increases the ed50	d
22	hypnotics like diazepam or nitrazepam have short pharmacological action(6-8 hours) because a.because their elemination  t1/2 is 6-8 hours b.due to redistribution c.both of these d.none of these	c
23	in a healthy person (70 kg),total fluid volume is 42 litr(approx).which involve i..14 litre extracellular fluid ii.28 litre intracellular fluid iii. plasma=4 litr iv.interstitial fluid=10 litre select the correct group a.i,ii,iii,iv b.i,ii,iii c.i,ii,iv d.i,ii only	a
24	which of the pair is not highly vascular a.heart,lung b.liver,brain c.kidney,lung d.muscle,fatty tissue	d
25	drugs with high molecular weight and high plasma protein binding also hydrophilic in nature mainly restricted to a.extracellular compartment b.intracelluar compartment c.both of these d.none	a
26	which statement is correct a.streptomycin and gentamicin are hydrophilic so these drugs mainly restriced to extra fluid compartment b.digoxin,propranolol,morphine show large volume of distribution c.drugs which show large volume of distribution are not easily removed by haemodialysis in case of poisioning d.all of these	d
27	factors which affect volume of disribution a.disease like chf, uremia,cirrhosis b.fat c.pka d.plasma protein binding correct statement is a.i,iii,iv b.i,ii,iii,iv c.i,ii,iii d.ii,iii,iv	b
28	drug concentrated in adipose tissue i.thiopentone ii.ddt iii.digoxin iv.minocycline correct statement a.i,ii,iii b.i,ii,iv c.ii,iii,iv d.i,iii,iv	b
29	orally administered sabine polio  vaccine is absorbed by a.pinocytosis b.phagocytosis c.ion transport d.all of these	a
30	acidic drugs generally bound to a.albumin b.alpha 1 acid glycoprotein c.both of these d.tyrosine	a
31	select the drug which show important displacement interactions a.sulfonamide displace bilirubin b.vitmin k displace bilirubin c.salicylates displace sulfonylureas d.all of these	d
32	high degree of protein binding a.make drug long acting b.bound drug not available for metabolism c.highly protein binding drugs are not removed by haemodialysis in case of poisioning d.all of these	d
33	primary site of drug metabolism is a.liver b.kidney c.lungs d.intestine	a
34	select the group which is not a  prodrug (group) a.levodopa,dipivefrine b.sulindac,sulfasalazine c.proguanil,mercaptopurine d.losartan,imipramine	d
35	select the phase ii reaction a.reduction b.oxidation c.acetylation d.hydrolysis	c
36	microsomal enzymes present on/in a.smooth endoplasmic reticulum b.cytoplasm c.mitochondria d.plasma	a
37	select the microsomal enzymes a.monooxygenase b.cyt-p450 c.glucuronyl transferase d.all of these	d
38	non microsomal enzymes catalysed all reaction except a.oxidation b.reduction c.sulfate conjugation d.glucuronidation	d
39	drugs which metabolised by enzyme a.allopurinol by xanthine oxidase b.adrenaline by monoamine oxidase c.succinyl cholie by cholinestrase d.all of these	d
40	select the follwing which cause microsomal enzyme induction a.drugs like phenobarbiton,isoniazid,griseofulvin,rifampin b.carcinogens c.insecticides d.all of these	d

TARGET GPAT- 2018--General Pharmacology MCQs series-1

1.	select the drug given sub lingualy a.gtn b.buprenorphine c.both of these d.none of these	c
2	select the abosorption paterrn  in descending order a.i.v.>oral>s.c.>i.m. b.i.v.>i.m.>oral>s.c. c.i.v.>i.m.>s.c.>oral d.oral>i.v.>s.c.>i.m.	c
3	which of the following is true for s.c.route i.irritants drug cannot injected ii.only small volume injected and self injection is possible iii.this route is preferred in shock patient due to vasoconstriction iv.depot preparation that are aqueous suspension can be injected for prolonged action select the right statement a.i,ii,iii b.ii,iii,iv c.i,ii,iv d.i,ii,iii,iv	c
4	select true statement i.subcutaneous tissue is highly supplied with sensory nerve fibres ii.muscle is less supplied with sensory nerves iii.s.c. tissue is less vascular iv.i.m. tissue is more vascular as compared to s.c.tissue chooose true statement a.i,ii,iiii,iv b.i,ii,iii c.i,ii,iv d.ii,iii,iv	a
5	which of the following is true for i.m..route i.mild irritants drug can be injected ii. self injection is possible iii.oily solutios and aqueous suspension can be injected by this route iv.im. injection should be avoided in anticoagulant treated patients select the right statement a.i,ii,iii b.ii,iii,iv c.i,ii,iv d.i,iii,iv	d
6	which preparation should be avoided through i.v. route a.aq. solution b.aq suspension c.suspuensions d.both b and c	d
7	which of the following is true for i.v..route i.highly  irritants drug can be injected ii. self injection is possible iii.aqueous suspension can be injected by this route iv.thrombophlebitis of injected vein select the right statement a.i,ii b.i,iv c.i,ii,iv d.i,iii,iv	b
8.	bcg  vaccine is injected by which route a.s.c b.i.m. c.oral d.intra dermal	d
9	sensitivity testing is done through which route a.s.c b.i.m. c.oral d.intra dermal	d
10	dermojet, pellet implantation and sialistic and biodegradeble implants are some special form of s.c. route,,,,,norplants (contraceptives)  tried through which special form of s.c. route a.dermojet b. pellet implantation c.sialistic and biodegradeble implants d.all of these	c
11	which of the following is  a  acidic drug a.sodium phenobarbitone b.sodium sulfadiazine c.potassium penicillin v d.all of these	d
12	weakly acidic drugs form salt with a.cation b.anion c.both of these d.none of these	a
13	a basic drug which have pka value  more than 11 a.ionoize at all ph b.ionize in alkaline ph only c.unionize at all ph d.ionize in acidic ph only	a
14	a drug easily cross git barrier if a.unionized and hydrophilic b.ionized and hydrophilic c.unionized and lipophilic d.ionized and hydrophilic	c
15	which of the following is nonelectrolyte a.ethanol b.atropine sulfate c.diethyl ether d.both a and c	d
16	paracellular spaces absent in a.git capillaries b.brain capillaries c.both of these d.none of these	b
17	which is not true about facilitated diffusion a.transport from high concen. to low concen b.entry of glucose in muscle cell by glut4 is example of facilitated diffusion c.energy requirment d.it is a type of carrier transport	c
18	the addition of glucuronic acid to a drug: a. decreases its water solubility. b. usually leads to inactivation of the drug. c. is an example of a phase i reaction. d.involves cytochrome p450.	b
19	a drug, given as a 100-mg single dose, results in a peak plasma concentration of 20 µg/ml. the apparent volume of distribution is (assume a rapid distribution and negligible elimination prior to measuring the peak plasma level): a. 0.5 l. b. 1 l. c. 2 l. d. 5 l	d
20	a drug with a half-life of 12 hours is administered by continuous iv infusion. how long will it take for the drug to reach ninety percent of its final steady-state level? a. 18 hours. b. 24 hours. c. 30 hours. d. 40 hours.	d