Time: 1 hour GPAT
ADDA ACADEMY Test
No.- 3
I CAN AND I WILL………
(Vinayak complex,
D-park, rohtak, contact no. 8901408422, 9671935154)
|
1.
|
Cystitis
is side effect of cyclophosphamide, it can be blocked/reduced by using
A.mesna b.acetylcysteine c.either a or b d.none of these
|
C
|
|
2.
|
Toxicity
of methotrexate can be overcome by
a.folic
acid b.folinic acid c.both of these d.none of these
|
B
|
|
3.
|
For
contolling cytotoxic drug induced vomiting, preferred antivomiting drug is
a.metoclopramide b.ondansetron c.dexamethasone d.lorazepam
|
B
|
|
4.
|
Select
the cell cycle specific anticancer drug
A.cyclophosphhamide b.etoposide c.procarbazine d.all of these
|
B
|
|
5.
|
Vincristine
is a cell cycle specific drug, it act on which phase
A.G1 B.M c.G2
d.S
|
B
|
|
6.
|
Antimetabolites
act on which phase
A.G1 b.M C.G2 D.S
|
D
|
|
7.
|
Major
side effect of doxorubicin/daunorubicin
a.neuropathy B. cardiotoxicity C. both of these d. cystitis
|
B
|
|
8.
|
Prominent
side effect of vincristine
A.neuropathy B.cardiotoxicity C.both of these D.cystitis
|
A
|
|
9.
|
Taxane
is obtained from
a.bark B. root C. leaves D. stem
|
A
|
|
10.
|
Taxane
are approved for
A.ovarian
cancer B.breast cancer C. both of these D. none of these
|
C
|
|
11.
|
Vincristine
act by
A.enhancing
polymerisation of tubulin protein
B.by
preventing polymerisation of tubulin
C.both
of these
D.any of the above
|
B
|
|
12.
|
Etoposide
used as anticancer drug, it is
A.natural B.semi-synthetic C.synthetic D.both b and c
|
B
|
|
13.
|
Topotecan
and irinotecan(semi synthetic) are obtained from a chinese tree, they act by
inhibiting function of enzyme
A.topoisomerase
–I B.topoisomerase-II C.DNA gyrase D.all of these
|
a
|
|
14.
|
L
–asparginase is a anticancer drug,it act by
A.
Inhibiting l-asparagine synthase
B.
By acting on l –asparginase which convert l-asparagine to l-aspartic acid
C.By
acting on l –asparginase which convert l-aspartic acid to l-asparagine
D.both
a and b
|
B
|
|
15.
|
Imatinib act by inhibiting
A.tyrosine
protein kinase B.tubulin
protein polymerisation
C.both
of these D.any
of the above
|
A
|
|
16.
|
Tumor
is detect when its minimum cell count is near by
A.109 B.1011 C.107 D105
|
A
|
|
17.
|
Select
the antimetabolite which is purine antagonist
A.azathioprine B.fludarabine C.cyatarabine D.both a and b
|
D
|
|
18.
|
Highly
emetogenic anticancer drug is
A.cisplatin B.ifosfamide C.busulfan D.etoposide
|
A
|
|
19.
|
Chloramphenicol
inhibit protein synthesis by by binding at ribosome
A.30s B.50s C.30 and 50 D.either 30 or 50
|
B
|
|
20.
|
Alkylating
agent generate highly active carbonium ion. Which position of guanine is
highly susceptible
A.7 B.1 C.10 D.6
|
A
|
|
21.
|
Select
wrong statement
A.ifosfamide
generate chloacetaldehyde active metabolite due to which ifosfamide is more
neurotoxic than cyclophosphamide
B.
Acrolein is metabolite of cyclophosphamide and ifosfamide due to this they
both cause haemorrhagic cystitis.
C.
Periwinkle is common name of podophyllotoxin anticancer drug
D.vincristine
drug cause more side effect in adults than children
|
C
|
|
22.
|
Which
of the following is natural source of taxane
A.taxus
brevifolia b.western yew
tree c.pacific yew tree
d.all
a, b,c e. Both a and b
|
D
|
|
23.
|
Stocking
and glove type of neuropathy is caused by
A.vincristine b. Vinblastine c.paclitaxel d. All
|
C
|
|
24.
|
Which
of the following are anthracycline antibiotic
1.adriamycin 2.doxorubicin 3.daunorubicin 4.rubidomycin
Select
correct
a.
Both 2 and 4
b.2,3,4 c.1,2,3,4 d.1,2,3
|
C
|
|
25.
|
Select
the drug which are used in toxicity of cancer drug
A.
Dexrazoxane in case of anthracyclin antibiotic
B.Glucarapidase
in case of methotrexate
C.Mesna
in case of cyclophosphamide related haemorrhagic cystitis toxicity.
D.
Amifostine is used for reduction of cisplatin induced nephrotoxicity
e.
All are correct
|
e
|
|
26.
|
Select
selective estrogen receptor modulator drug
A.Tamoxifen b.Imatinib
c.Fulvestrant d.None
|
A
|
|
27.
|
Select
monoclonal antibody which is not used in cancer
A.Rituximab b.Cetuximab c.Abciximab d.Trastuzumab
|
C
|
|
28.
|
Which
one of the following is liquid alkaloid and volatile in nature
A.Ephedrine b.Aconite c.Nicotine d.All
|
C
|
|
29.
|
Which
of the following is pseudoalkaloid
A.Taxol b.Solanidine
c.Aconotine d.All
|
D
|
|
30.
|
Emetine
is type of
A.indole
alkaloid b.isoquinoline c.tropane d.quinoline
|
B
|
|
31.
|
Arecoline
and lobeline obtained from(precursor)
A.lysine b.ornithine c.tryptophan d.tyrosine
|
A
|
|
32.
|
Which
of the following is also known as DEADLY NIGHT SHADE LEAF
A.hyoscyamus
niger b.datura metel c.belladona d.stramonium
|
C
|
|
33.
|
Which
of the following is adulterant of belladonna
A.phytolacca
Americana b.ailanthus glandulosa c.solanum nigrum d.all
|
D
|
|
34.
|
Which
of the following is also known as THORN APPLE LEAF
A.hyoscyamus
niger b.datura metel c.belladona d.stramonium
|
D
|
|
35.
|
Vitali
morin test is give positive test for tropane alkaloid, it give which type of
colour
a.Yellow b.brown c.violet
d.orange
|
C
|
|
36.
|
Name
the vitamine essential for tissue culture
A.thiamine
b. Riboflavin c. Biotin d.pyridoxine
|
A
|
|
37.
|
Precursor
of ephedrine
A.phenylalanine b.tyrosine c.ornithine d.tryptophan
|
A
|
|
38.
|
Precursor
of papaverine, thebaine
A.phenylalanine b.tyrosine c.ornithine d.tryptophan
|
B
|
|
39.
|
Precursor
of qunine and indole alkaloid
A.phenylalanine b.tyrosine c.ornithine d.tryptophan
|
D
|
|
40.
|
Precursor
of l-hyoscyamine
A.phenylalanine b.tyrosine
c.ornithine
d.tryptophan
|
C
|
|
41.
|
Tryptophan,
phenylalanine, tyrosine are synthesized through
A.shkimic
acid pathway b.mevalonate pathway c. Both d.none
|
A
|
|
42.
|
Which
type of stomata present in digitalis, fennel, opium, Artemisia, feverfew
A.anomocytic b.actinocytic c.anisocytic d.diacytic
|
A
|
|
43.
|
Which
type of stomata present in datura, belladonna, stramonium and vinca
A.anomocytic b.actinocytic c.anisocytic d.diacytic
|
C
|
|
44.
|
Which
type of stomata present in coca and senna
A.anomocytic b.actinocytic c.cruciferous d.paracytic
|
D
|
|
45.
|
Another
name of paracytic stomata
A.caryophyllaceous b.cruciferous c.ranunculaceous d.rubiaceous
|
D
|
|
46.
|
Another
name of diacytic stomata
A.caryophyllaceous b.cruciferous c.ranunculaceous d.rubiaceous
|
A
|
|
47.
|
Another
name of anisocytic stomata
A.caryophyllaceous b.cruciferous c.ranunculaceous d.rubiaceous
|
B
|
|
48.
|
Another
name of anomocytic stomata
A.caryophyllaceous b.cruciferous c.ranunculaceous d.rubiaceous
|
C
|
|
49.
|
Paracytic
stomata is
a.
2 guard cell covered by 2 subsidiary cell
b.
Arrangement of subsidiary cell is at right angle
c.
Guard cell covered by 3 subsidiary cells
d.
Various no. Of subsidiary cell
|
A
|
|
50.
|
Diacytic
stomata is
a.
2 guard cell covered by 2 subsidiary cell
b.
Arrangement of subsidiary cell is at right angle
c.
Guard cell covered by 3 subsidiary cells
D. Various no. Of subsidiary cell
|
B
|
|
51.
|
Anisocytic stomata is
a.
2 guard cell covered by 2 subsidiary cell
b.
Arrangement of subsidiary cell is at right angle
c.
Guard cell covered by 3 subsidiary cells
D. Various no. Of subsidiary cell
|
C
|
|
52.
|
Stomata
present on fruit
a.
Colchicum b. Ephedra c.fennel d.clove
|
C
|
|
53.
|
Stomata
present on flower
A.colchicum b. Ephedra c.fennel d.clove
|
D
|
|
54.
|
Hand
and foot syndrome is not is caused by
a.capecitabine b.doxorubicin c.hydroxyurea d.all
|
C
|
|
55.
|
Select
wrong pair:
a.cyclophosphamide
and capecitabine 1.prodrugs of
5-fluoro uracil
b.antimetabolite
drugs
2. Bone marrow depression
c.nitrosourea 3. Delayed
neutropenia
d.
cytotoxic drugs act through 4.1st order kinetic
e.
estramustine
5. Estrogen+mechlorethamine
|
|
|
56.
|
Select
wrong
a.
Cyclosporine cause hirsutism, hyperuricemia,
nephrotoxicity, hepatotoxicity, hypertension, neurotoxicity, hyperlipidemia,
hyperglycemia, hyperkalemia and gum hyperplasia.
b.
Tacrolimus is a macrolide antibiotic and less
toxic than cyclosporine
c.
Rheumatoid arthritis, Psoriasis, Graves disease
are autoimmune disorder
d.
Azathioprine is prodrug used as immunosuppressant
but less/not used in cancer
e.
Cyclosporine inhibit B and T lymphocytes
|
E
|
|
57.
|
Most
commonly used immunosuppressant
a.cyclosporin b.tacrolimus c.glucocorticoid d.methotrexate
|
C
|
|
58.
|
Methotrexate
not used in
a.psoriasis b.cancer c.rheumatoid arthritis d.immunosuppressant e.anemia
|
E
|
|
59.
|
Find
wrong one:
a.
Cytokine act through transmembrane enzyme linked
receptor
b.
Interferon act though JAK-STAT receptor
c.
Nerve growth factor (NGF) act through
transmembrane enzyme linked receptor
d.
Epidermal growth factor (EGF) act through transmembrane
enzyme linked receptor
|
A
|
|
60.
|
Which
of the following is not alkylating agent
a.mechloetahmine b.azathioprine c.dacarbazine d.chlorambucil
|
b
|
|
61.
|
Which
of the following alkaloids are found as salt of meconic acid
A
ergot B codeine C rauwolfia D opium
|
D
|
|
62.
|
Precursor
for synthesis of ornithin
A
tropane B indole C quinoline D all of these
|
A
|
|
63.
|
Opium
does not cantain the following except
A
meconic acid B
starch C calcium
oxalate D tannin
|
A
|
|
64.
|
Rauwalfia
is belonging to which class
A
isoquinoline alkaloids B
tropane C indole D quinazoline
|
C
|
|
65.
|
Ipecacunhana
is belonging to which class
A
isoquinoline alkaloids B
tropane C indole D quinazoline
|
A
|
|
66.
|
Which
of following drug show oxytoxic effect
A
Ipecacunhana B
cinchona C coca D ergot
|
D
|
|
67.
|
Saturated
aqueous solution of picric acid is also known as
A
mayers reagent B hagers reagent C wagners reagent D dragendroffs reagent
|
B
|
|
68.
|
Murexide
test shown by which drug
A
uric acid B theophylline C caffeine D theobromine e. both a and c
|
e
|
|
69.
|
Thylloqunine
test for
A
Ipecacunhana B
cinchona C coca D ergot
|
B
|
|
70.
|
Van-verck
reagent used for
A
Ipecacunhana B
cinchona C coca D ergot
|
D
|
|
71.
|
Steroidal
alkaloids is
A
conessine B quinine C vasicine D reserpine
|
A
|
|
72.
|
Which
alkaloids contains phanenthrene derivative
A
atropine B morphine C quinine D nicotine
|
B
|
|
73.
|
Which
alkaloids contains quinozoline moiety
A
cocaine B quinine C vasicine D narcotine
|
C
|
|
74.
|
Alkaloid
not precipitated by
A
mayers reagent B hagers
reagent C picric acid D million reagent
|
D
|
|
75.
|
The
chemical behavior of morphine
A
acidic B basic C neutral D amphoteric
|
B
|
|
76.
|
Cinchocaine
is derivative of
A
quinoline B isoquinoline C N-methyl piperidine D 2-methyl pyridine
|
A
|
|
77.
|
Alkaloid
with secondary amine nitrogen
A
mescaline B atropine C ephedrine D tubocuranine
|
C
|
|
78.
|
Which
drug give blue fluorescence in water
A
ergotamine B ergometerine C
ergometerinine D all of
these
|
B
|
|
79.
|
Which
drug contains glycoside constitute present
A
nux vomica B indole C ergot D cincohana
|
A
|
|
80.
|
Which
drug Arresting mitosis at the metaphase stage
A
vinca B ruawalifia C opium D none of these
|
A
|
|
81.
|
Largest
Production of opium
A
India B America C Afghanistan D none
|
C
|
|
82.
|
Frohdes
reagent used for
A
Ipecacunhana B cinchona C coca D ergot
|
A
|
|
83.
|
Calcium
oxalate is absent
A
vinca B ergot C nux vomica D all of the above
|
D
|
|
84.
|
Sunken
sotamata present in
A
mescaline B atropine C ephedrine D tubocuranine
|
C
|
|
85.
|
Quniidine
is used
A
antimalerial B
anti-arrthythemic C
antimuscarinic D antidysentry
|
B
|
|
86.
|
Match
stick test is used for
A
ellagic acid B
catechine C sinigrine D none e. both b and c
|
e
|
|
87.
|
Arrange
the following Carbonium ions in the order of increasing stability
(a)
Benzyl > tertiary > secondary > primary
(b)
Benzyl > primary > secondary >tertiaty
(c)
Tertiary> secondary > primary > Benzyl
(d)
Primary> secondary > tertiary > benzyl
|
A
|
|
88.
|
In
Carbonium ions, the positive charge is carried by carbon atom with
____________electrons in the valence shell
(a)
6 (b) 5 (c) 4 (d) 3
|
A
|
|
89.
|
The
hybridisation state of carbanion is
(a)
sp (b) sp2 (c) sp3 (d) sp3d
|
C
|
|
90.
|
-I
effect
(a)
increases the stability of carbanions
b) decrease the stability of carbanions
(c)
stability remains same (d) none of the
above
|
A
|
|
91.
|
The
charge of carbanion can be dispersed by
(a)
+I effect and resonance b) –I effect and
resonance
(c)
Hyperconjugation d)
Mesomeric effect and resonance
|
B
|
|
92.
|
Hyperconjugation
is responsible for the delocalisation of
(a) σ bond orbital b) π bond orbital
(c) both σ and π bond orbitals (d) none of the mentioned
|
A
|
|
93.
|
Number
of hyperconjugation structures in tert-butyl radical is
(a)
3 b) 6 (c) 9 (d) 12
|
C
|
|
94.
|
Which
compound is most acidic?
(a)
FCH2CO2H (b)
ClCH2CO2H (c)
BrCH2CO2H
(d) ICH2CO2H
|
A
|
|
95.
|
SN2
reactions involves
(a)
Inversion of configuration
(b)
Slightly more inversion than retention
(c)
Slightly more retention than inversion
(d)
Retention of configuration
(e)
Equal amount of inversion and retention of configuration
|
A
|
|
96.
|
An
activated complex is a chemical entity that is
a.
Stable and has low potential energy
b.
Stable and has high potential energy
c.
Unstable and has low potential energy
d.
Unstable and has high potential energy
|
D
|
|
97.
|
Which
molecule or ion plays the role of acid in the following reaction?
a.
HNO3
b.
H2SO4
c.
HSO4-
d.
H2NO3+
|
B
|
|
98.
|
Bacteria which need oxygen for growth
are called
a.
Thermophilic bacteria
b. Microaerophilic bacteria
c. Facultative
anaerobic bacteria d. Mycobacteria
|
B
|
|
99.
|
Endotoxin are:
(a)
Class of pyrogen (b) Lipopolysaccrides in nature
(c)
Componets of cell wall of gram negative bacteria (d)all
|
D
|
|
100.
|
The strain of fungi used for the large scale production of penicillin
is
a. Penicillium
chrysogenum
b. P-notatum
c.
Streptomyces Aurecus d.
Saccharomyces sps
|
A
|
